Application of novel nosocomial infection prevention and control combined with intestinal probiotics in children with hand, foot and mouth disease.

2025-10-04
JPMA. The Journal of the Pakistan Medical Association 75(7 (July) (Supple-02))
- Yuqiong Tao
- Huibin Lu
- Jinlian Huang
- E Tang
- Xiaoyan Xu
- Jianhui Xie

PubMed: 41248651
DOI: 10.47391/jpma.srph-22

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 100
Population: 100 paediatric inpatients with hand, foot and mouth disease
Methods: Randomised case-control study, bacillus coagulans live tablets along with novel nosocomial infection prevention and control measures vs conventional treatment with basic nursing services

Large Human Trial

Objective

To explore the effect of novel nosocomial infection prevention and control combined with intestinal probiotics in children with hand, foot and mouth disease.

Methods

The randomised case-control study was conducted at the Hunan Children's Hospital, Changsha, China, from January 2022 to December 2023, and comprised of paediatric inpatients with hand, foot and mouth disease. The patients were randomised into control Group 1 receiving conventional treatment with basic nursing services, and intervention Group 2 receiving bacillus coagulans live tablets along with novel nosocomial infection prevention and control measures. The time of symptom resolution, fever resolution, length of hospital stay, clinical effect, serum inflammatory factors, immune function, incidence of adverse reactions, quality of life and parents' satisfaction with nursing were noted and compared between the groups. Data was analysed using SPSS 22.0.

Results

Of the 100 patients, 50(50%) were in Group 1; 25(50%) boys and 25(50%) girls with mean age 3.49±1.93 years. There were 50(50%) patients in Group 2; 26(52%) boys and 24(48%) girls with mean age 3.52±2.03 years (p>0.05). Compared to Group 1, patients in Group 2 had shorter time of symptom resolution, fever resolution, length of hospital stay, better total effective rate, lower frequency of adverse reactions and higher nursing satisfaction (p<0.05). After the intervention, improvements in serum inflammatory factors in Group 2 were more significant, the immune function indexes were higher, and the quality of life scores were better compared to Group 1 (p<0.05).

Conclusions

Novel nosocomial infection prevention and control combined with intestinal probiotics could promote the therapeutic effect of the children, improve the immune function, and promote the quality of life of children with hand, foot and mouth disease.

Research Insights

Bacillus coagulans→Improved Clinical Response Rate
patients in Group 2 had ... better total effective rate (p<0.05)
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Improved Immune Function
the immune function indexes were higher (p<0.05)
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Improved Quality of Life
the quality of life scores were better compared to Group 1 (p<0.05)
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Fever Resolution Time
patients in Group 2 had shorter time of ... fever resolution ... (p<0.05)
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Inflammatory Factor Level
After the intervention, improvements in serum inflammatory factors in Group 2 were more significant (p<0.05)
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Length of Hospital Stay
patients in Group 2 had shorter ... length of hospital stay (p<0.05)
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Time to Symptom Resolution
patients in Group 2 had shorter time of symptom resolution ... (p<0.05)
Effect
Beneficial
Effect size
Small

Adverse Events Reported

Bacillus coagulans→Overall tolerability
Compared to Group 1, patients in Group 2 had ... lower frequency of adverse reactions ... (p<0.05)
Finding
Reported