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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The effect of short-term consumption of Bifidobacterium bifidum on the gut microbiome of obese individuals.
- 2026-02-23
- Experimental biology and medicine (Maywood, N.J.) 251
- - Inna Burakova
  - Yuliya Smirnova
  - Polina Morozova
  - Svetlana Pogorelova
  - Olga Kryukova
  - Tatiana Kislova
  - Olga Korneeva
  - Mikhail Syromyatnikov
- PubMed: 41809656
- DOI: 10.3389/ebm.2026.10894
1 Insight on
- Improved Gut Microbiome Composition
- Low evidence
Advances in genome-scale metabolic modeling of Bacillus subtilis.
- 2026-02-23
- Review
- Biotechnology letters 48(2)
- - Pınar Kocabaş
- PubMed: 41729311
- DOI: 10.1007/s10529-026-03712-w
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Therapeutic Potential and Mechanistic Pathways of Plant-Based Supplements and Exercise Training in Blood Pressure Management: An Evidence-Based Review and Research Agenda.
- 2026-02-22
- Review
- Nutrients 18(4)
- - Behzad Taati
  - Georgian Badicu
  - Jolita Vveinhardt
- PubMed: 41754217
- DOI: 10.3390/nu18040700
1 Insight on
- Reduced Blood Pressure
- Moderate evidence
- Rigorous Journal
Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders.
- 2026-02-21
- Review
- Amino acids 58(1)
- - Tushar Adhikari
  - Prerona Saha
- PubMed: 41721117
- DOI: 10.1007/s00726-026-03505-5
6 Insights on
- Low evidence
Effects of Probiotics in Pregnant Women with Gestational Diabetes Mellitus: An Overview of Systematic Reviews.
- 2026-02-21
- Review · n = 16
- International journal of general medicine 19
- - Huixia Ren
  - Naijin Zhang
  - Yonghui Li
  - Yingxiang Li
  - Mengyang Wang
  - Huaien Bu
  - Hongwu Wang
- PubMed: 41756807
- DOI: 10.2147/ijgm.s576626
8 Insights on
- Low evidence
Surface Layer-Associated Protein on Nanoparticles from Lactobacillus helveticus Enhances the Response to LPS in RAW264.7 Cells.
- 2026-02-21
- Current microbiology 83(4)
- - Chika Yamamoto
  - Nao Fujiwara
  - Ika Adhani Sholihah
  - Mana Yamamoto
  - Rinka Kizaki
  - Daichi Ito
  - Chinatsu Yokoi
  - Saho Furukawa
  - Hiroko Koyama
  - Yoko Hirata
  - Kyoji Furuta
  - Hiroshi Takemori
- PubMed: 41721904
- DOI: 10.1007/s00284-026-04783-8
2 Insights on
- Enhanced Immune Response
- Increased Inflammatory Mediator Production
- Low evidence
- Animal Study
Effects of different vitamin D supplements on body fat distribution and glucolipid metabolism in patients with obesity-associated metabolic syndrome: A meta-analysis.
- 2026-02-20
- Meta-Analysis
- Medicine 105(8)
- - Qin Huang
  - Jidong Zhan
  - Yuan Gui
  - Ming Ma
  - E Li
- PubMed: 41731803
- DOI: 10.1097/md.0000000000047436
4 Insights on
- High evidence
The role of bovine colostrum in feeding intolerance in preterm neonates: a systematic review and meta-analysis of randomized controlled trials.
- 2026-02-20
- Systematic Review · n = 670
- Frontiers in nutrition 12
- - Jia Yao
  - Bo Zheng
  - Jie Zhang
  - Fen Xu
  - Jianbo Zhuang
- PubMed: 41798170
- DOI: 10.3389/fnut.2025.1668500
3 Insights on
- High evidence
Preload time-dependent effects of Panax ginseng on postprandial glucose tolerance. A randomized controlled study in healthy middle-aged participants.
- 2026-02-20
- Clinical Trial
- Frontiers in nutrition 13
- - Anne Nilsson
- PubMed: 41798830
- DOI: 10.3389/fnut.2026.1759162
2 Insights on
- Improved Insulin Levels
- Reduced Postprandial Glucose
- High evidence
Multi-omics reveals microbial community characteristics and flavonoid biotransformation mechanisms during mung bean sour fermentation.
- 2026-02-20
- Current research in food science 12
- - Xunda Wang
  - Yuxia Yang
  - Yue Li
  - Ziqi Zhu
  - Reham Khashaba
  - Qinghua Yue
- PubMed: 41717629
- DOI: 10.1016/j.crfs.2026.101342
2 Insights on
- Enhanced Flavonoid Metabolism
- Reduced Flavonoid Levels
- Low evidence
Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.
- 2026-02-20
- BMC microbiology 26(1)
- - Siloni Patial
  - Khem Raj
  - Geeta Shukla
- PubMed: 41721244
- DOI: 10.1186/s12866-026-04840-z
11 Insights on
- Low evidence
Therapeutic potential of L-carnitine in coronary artery disease: a systematic review.
- 2026-02-19
- Systematic Review · n = 21
- Inflammopharmacology 34(3)
- - Rehab H Werida
  - Sherouk M Okda
- PubMed: 41709059
- DOI: 10.1007/s10787-025-02048-7
3 Insights on
- High evidence
Microbiota management: a perspective for kidney transplant patients.
- 2026-02-19
- Review
- Frontiers in transplantation 5
- - Cláudia Silva Souza
  - Niels Olsen Saraiva Camara
  - Thaís Alves-Silva
- PubMed: 41798990
- DOI: 10.3389/frtra.2026.1703048
7 Insights on
- Low evidence
Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa.
- 2026-02-19
- NPJ biofilms and microbiomes 12(1)
- - Vanessa Croatti
  - Caroline Dricot
  - Tom Eilers
  - Jelle Dillen
  - Tim Van Rillaer
  - Eline Cauwenberghs
  - Ilke Van Tente
  - Sam Bakelants
  - Dieter Vandenheuvel
  - Camille Allonsius
  - Isabel Pintelon
  - Sofie Thys
  - Wendy Mensah
  - Marina Naldi
  - Peter A Bron
  - Stijn Wittouck
  - Irina Spacova
  - Carola Parolin
  - Beatrice Vitali
  - Sarah Lebeer
- PubMed: 41714642
- DOI: 10.1038/s41522-026-00937-5
3 Insights on
- Low evidence
Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review.
- 2026-02-19
- Review
- Frontiers in microbiology 17
- - Carlos Patricio Acosta Rodríguez Bueno
  - Ailim Carias Domínguez
  - Denis Guyonnet
  - Etienne Pouteau
- PubMed: 41800422
- DOI: 10.3389/fmicb.2026.1773473
8 Insights on
- Low evidence
Maternal gut microbiota mediates prenatal stress-induced fetal blood‒brain barrier dysfunction.
- 2026-02-19
- Gut microbes 18(1)
- - Xuanping Wang
  - Fang-Yue Zhou
  - Ting Wu
  - Chenchi Duan
  - Xukai Luo
  - Yicong Meng
  - He-Feng Huang
  - Yan-Ting Wu
- PubMed: 41715909
- DOI: 10.1080/19490976.2026.2631242
1 Insight on
- Reduced Fetal Blood-Brain Barrier Dysfunction
- Low evidence
- Animal Study
Saccharomyces boulardii CNCM I-745 and smectite treatment for pediatric acute gastroenteritis in China: a systematic review and meta-analysis.
- 2026-02-19
- Review · n = 767
- Frontiers in pediatrics 14
- - Tong Li
  - Lynne Vernice McFarland
- PubMed: 41798274
- DOI: 10.3389/fped.2026.1747695
6 Insights on
- High evidence
Transcriptomic responses of Saccharomyces boulardii to the germ-free mouse gut.
- 2026-02-18
- BMC genomics 27(1)
- - Genan Wang
  - Deniz Durmusoglu
  - Nathan Crook
- PubMed: 41709131
- DOI: 10.1186/s12864-026-12661-7
1 Insight on
- Altered Gut Microbial Transcriptomic Response
- Low evidence
Enhanced editing of Bifidobacterium lactis using the endogenous Type I-G CRISPR-Cas system.
- 2026-02-18
- Applied and environmental microbiology 92(2)
- - Ourania Raftopoulou
  - Kendall Malmstrom
  - Meichen Pan
  - Rodolphe Barrangou
- PubMed: 41524418
- DOI: 10.1128/aem.01839-25
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery.
- 2026-02-18
- Review
- Frontiers in pharmacology 17
- - Emanuela Ribichini
  - Giulia Scalese
  - Chiara Mocci
  - Natascia De Amicis
  - Carola Severi
- PubMed: 41788803
- DOI: 10.3389/fphar.2026.1738562
2 Insights on
- Improved Stool Consistency
- Improved Stool Frequency
- Low evidence
In vitro digestion and fermentation of ginseng pectic polysaccharide GPS-1 and attenuation of its product on oleic acid-induced oxidative stress in HepG2 cells.
- 2026-02-18
- Frontiers in pharmacology 17
- - Xiwen Sun
  - Li Liu
  - Wenbo Jiao
  - Ting Ren
  - Ran Zhao
  - Zirui Tan
  - Ziye Jiang
  - Jing Wang
  - Bo Li
  - Xiaoyu Zhang
  - Lili Jiao
- PubMed: 41788794
- DOI: 10.3389/fphar.2026.1758770
3 Insights on
- Low evidence
Impact of Pediococcus acidilactici and tylvalosin on porcine Enterobacterales abundance, antimicrobial resistance, and conjugative potential.
- 2026-02-18
- Clinical Trial
- Journal of applied microbiology 137(3)
- - Annie Turcotte
  - Dominic Poulin-Laprade
  - Linda Saucier
  - Joanie Lemieux
  - Nathalie Gagnon
  - Sylvain Fournaise
  - Frédéric Guay
  - Vincent Burrus
  - Guylaine Talbot
- PubMed: 41707193
- DOI: 10.1093/jambio/lxag044
4 Insights on
- Low evidence
- Animal Study
Essential micronutrients and biguanides (metformin) synergistic and antagonistic interactions on neurocognitive outcomes in type two diabetes mellitus: a systematic review of preclinical and clinical evidence.
- 2026-02-17
- Systematic Review
- Frontiers in endocrinology 17
- - Herbert Izo Ninsiima
  - Herbert E Ainamani
  - Geoffrey Ayebazibwe
  - Daniel Matovu
  - Ejike Daniel Eze
- PubMed: 41782745
- DOI: 10.3389/fendo.2026.1764157
3 Insights on
- High evidence
Prebiotics, probiotics, and synbiotics and maternal mental health during pregnancy and postpartum period: a systematic review.
- 2026-02-17
- Systematic Review · n = 342
- Frontiers in nutrition 13
- - Sandra Martín-Peláez
  - Luis Miguel Martín-delosReyes
  - Naomi Cano-Ibáñez
- PubMed: 41783815
- DOI: 10.3389/fnut.2026.1776398
4 Insights on
- High evidence
Prebiotics, Probiotics, and Postbiotics for Acne Vulgaris: A Systematic Review.
- 2026-02-17
- Systematic Review
- Dermatology and therapy 16(3)
- - Peyton V Warp
  - Sophie M Bilik
  - Lina M Ferrari
  - Jonette E Keri
- PubMed: 41703218
- DOI: 10.1007/s13555-026-01659-4
6 Insights on
- High evidence
Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.
- 2026-02-17
- RCT
- mSystems 11(2)
- - Yingmeng Li
  - Qiong Li
  - Keyu Quan
  - Yong Xie
  - Ni Yang
  - Teng Ma
  - Longjin Zheng
  - Wei Zhou
  - Yalin Li
  - Hao Jin
  - Zhihong Sun
  - Yongfu Chen
  - Lai-Yu Kwok
  - Nonghua Lu
  - Weifeng Zhu
  - Wenjun Liu
  - Heping Zhang
- PubMed: 41609355
- DOI: 10.1128/msystems.01568-25
8 Insights on
- High evidence
- Rigorous Journal
Preventing Contrast-Induced Acute Kidney Injury in Egyptian Patients Undergoing Coronary Angiography: A Randomized Controlled Trial.
- 2026-02-17
- RCT · n = 120
- Clinical drug investigation 46(4)
- - Sarah Sabry
  - Mai K Ammar
  - Mahmoud Taeima
  - Noha Nassar
  - Azza ElFiky
  - Ayman Saleh
- PubMed: 41701447
- DOI: 10.1007/s40261-026-01524-4
1 Insight on
- Reduced Contrast-Induced Acute Kidney Injury
- High evidence
- Large Human Trial
Probiotic intervention not beneficial to prevent antibiotic-associated diarrhea in absence of antibiotic-induced microbiome disruption.
- 2026-02-16
- RCT
- Scientific reports 16(1)
- - Daniel Merenstein
  - Silvia Grant-Beurmann
  - Mary Ellen Sanders
  - Tina Tan
  - Brendan Burke
  - Aneesha Kumar
  - Keisha Herbin-Smith
  - Jessy Sparenborg
  - Frank D'Amico
  - Bob Roberts
  - Claire Fraser
- PubMed: 41699149
- DOI: 10.1038/s41598-026-39826-4
2 Insights on
- Reduced Antibiotic-Associated Diarrhea
- Reduced Antibiotic-Associated Gut Microbiome Disruption
- High evidence
- Rigorous Journal
Lactobacillus acidophilus KBL409 improves serum indoxyl sulfate via gut microbial changes in a human study.
- 2026-02-16
- RCT · n = 34
- NPJ science of food 10(1)
- - Sung Jae Jang
  - SungJun Park
  - Kiuk Lee
  - Woon-Ki Kim
  - Sung Hyun Moon
  - Bo-Ram Cho
  - Cheonghoon Lee
  - Hyungjin Lee
  - Tae-Wook Nam
  - GwangPyo Ko
- PubMed: 41698905
- DOI: 10.1038/s41538-026-00755-1
1 Insight on
- Reduced Indoxyl Sulfate Levels
- High evidence
Oral Administration of Lactobacillus amylovorus Alleviates Diarrhea by Restoring Gut Microbiota and SCFAs in Neonatal Goats.
- 2026-02-16
- Clinical Trial · n = 20
- Animals : an open access journal from MDPI 16(4)
- - Mudathir Y Abdulrahman
  - Nasir A Ibrahim
  - Mohamed Osman Abdalrahem Essa
  - Saber Y Adam
  - Raza Mohai Ud Din
  - Rifat Ullah Jan
  - Nosiba S Basher
  - Mokhtar Rejili
  - Shaaban S Elnesr
  - Ahmed A Saleh
  - Hosameldeen Mohamed Husien
  - Mengzhi Wang
- PubMed: 41751094
- DOI: 10.3390/ani16040633
4 Insights on
- Moderate evidence