Multicenter retrospective observational study on the clinical effectiveness of butyrate-producing Clostridium butyricum containing probiotics in patients with COVID-19.
- 2026-05-17
- Virulence 17(1)
- Yoshihiko Morikawa
- Hideo Kato
- Takumi Umemura
- Jun Hirai
- Yuichi Shibata
- Mao Hagihara
- Nobuhiro Asai
- Hiroshige Mikamo
- Takuya Iwamoto
- PubMed: 42127027
- DOI: 10.1080/21505594.2026.2673650
Study Design
- Type
- Observational
- Population
- patients with COVID-19 from 2020 to 2021
- Methods
- retrospective clinical study; patients divided into probiotic (27) and non-probiotic (256) groups; all received antiviral agents
Butyrate-producing bacteria, which are components of the gut microbiome, activate host defense mechanisms against several types of infections, including respiratory viral infections. However, the clinical effectiveness of butyrate-producing Clostridium butyricum (CB)-containing probiotics in patients with coronavirus disease 2019 (COVID-19) remains unclear. We investigated the in-hospital mortality, period of mechanical ventilation, and incidence of secondary bacterial pneumonia in patients with COVID-19 from 2020 to 2021. The patients were divided into the probiotic (27) and non-probiotic (256) groups. The two groups did not show a significant difference in the SOFA scores (probiotic vs. non-probiotic, 2.1 ± 2.3 vs. 2.1 ± 2.9). Additionally, all patients received antiviral agents to treat COVID-19; however, the two groups did not show significant difference in their distribution. However, patients receiving CB preparations showed the shorter periods of mechanical ventilation (1.1 ± 2.5 days vs. 3.9 ± 9.4 days). Although not statistically significant, they also showed lower incidence of secondary bacterial pneumonia (7.4% vs. 15.6%) and the lower in-hospital mortality (3.7% vs. 15.2%) compared to the non-probiotic group. This retrospective clinical study revealed that the administrations of CB preparations might attenuate clinical symptoms related to COVID-19 and improve mortality. However, further clinical and basic studies are required to validate our findings.
Research Insights
patients receiving CB preparations showed the shorter periods of mechanical ventilation (1.1 ± 2.5 days vs. 3.9 ± 9.4 days)
- Effect
- Beneficial
- Effect size
- Small
the lower in-hospital mortality (3.7% vs. 15.2%) compared to the non-probiotic group
- Effect
- Neutral
- Effect size
- Small
Although not statistically significant, they also showed lower incidence of secondary bacterial pneumonia (7.4% vs. 15.6%)
- Effect
- Neutral
- Effect size
- Small