Clostridium butyricum and Reduced In-hospital Mortality

• Multicenter retrospective observational study on the clinical effectiveness of butyrate-producing Clostridium butyricum containing probiotics in patients with COVID-19.

  • 2026-05-17
  • Observational
  • Virulence 17(1)
  • • Yoshihiko Morikawa
    • Hideo Kato
    • Takumi Umemura
    • Jun Hirai
    • Yuichi Shibata
    • Mao Hagihara
    • Nobuhiro Asai
    • Hiroshige Mikamo
    • Takuya Iwamoto

  • PubMed: 42127027
  • DOI: 10.1080/21505594.2026.2673650

  3 Insights on

  • Reduced In-hospital Mortality

  • Low evidence
  • Clinical

  the lower in-hospital mortality (3.7% vs. 15.2%) compared to the non-probiotic group

  Effect

  Neutral

  Effect size

  Small

  Significant

  No