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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of Dietary Nitrate and Caffeine on End Power and Work Above End Power During a 3 min All-Out Test in Trained Male Cyclists.
- 2026-05-02
- RCT
- Nutrients 18(9)
- - Anthony M Hagele
  - Kyle L Sunderland
  - Petey W Mumford
  - Chad M Kerksick
- PubMed: 42124064
- DOI: 10.3390/nu18091463
5 Insights on
- High evidence
- Rigorous Journal
Efficacy and Safety of a Dual-Wavelength 589/1319 nm Laser for the Treatment of Acne Erythema: A Split-Face Randomized Controlled Trial.
- 2026-05-01
- RCT
- Journal of cosmetic dermatology 25(5)
- - Suphagan Boonpethkaew
  - Pimsiri Anansiripun
  - Warittha Maitrisathit
  - Yanisa Ratanapokasatit
  - Sonphet Chirasuthat
  - Panrudee Wechsuruk
  - Penpun Wattanakrai
- PubMed: 42087432
- DOI: 10.1111/jocd.70894
1 Insight on
- Reduced Acne Erythema
- High evidence
Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
- 2026-05-01
- Review · n = 663
- Avicenna journal of phytomedicine 16(3)
- - Fatemeh Ghaemi
  - Maryam Emadzadeh
  - Wael Almahmeed
  - Tannaz Jamialahmadi
  - Sercan Karav
  - Amirhossein Sahebkar
- PubMed: 42153011
- DOI: 10.22038/ajp.2025.26398
4 Insights on
- High evidence
A child with cobalamin C deficiency caused by complex heterozygous variation of c.567dupT and c.80A > G complicated with pulmonary arterial hypertension and hydrocephalus: A case report and literature review.
- 2026-05-01
- Review
- Medicine 105(18)
- - Xuxia Cui
  - Yajing Zhong
  - Chongjuan Yin
- PubMed: 42065149
- DOI: 10.1097/md.0000000000048340
4 Insights on
- Low evidence
Comparative efficacy of pediatric atopic dermatitis treatments: a network meta-analysis highlighting dupilumab and pimecrolimus for SCORAD and EASI improvement.
- 2026-05-01
- Meta-Analysis · n = 3,961
- Frontiers in immunology 17
- - Liu Yang
  - Ruixue Hu
  - Yueyuan Wang
  - Yuanyuan He
- PubMed: 42148141
- DOI: 10.3389/fimmu.2026.1676852
1 Insight on
- Reduced SCORAD Score
- High evidence
Single intake of matcha increases brown adipose tissue activity in young women with low thermogenesis.
- 2026-05-01
- RCT · n = 30
- Physiological reports 14(9)
- - Hirokazu Taniguchi
  - Chisaki Hachikawa
  - Sana Iwase
  - Shinsuke Nirengi
  - Tomomi Nagahata
- PubMed: 42068075
- DOI: 10.14814/phy2.70896
1 Insight on
- Increased Brown Adipose Tissue Activity
- High evidence
Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
- 2026-04-30
- Review
- Endocrinology and metabolism (Seoul, Korea) 41(2)
- - Sung Hye Kong
- PubMed: 42114835
- DOI: 10.3803/enm.2026.2938
3 Insights on
- Low evidence
The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial.
- 2026-04-30
- RCT · n = 24
- Nutrients 18(9)
- - Kenneth Smith
  - Kenneth Smith
  - Haitham Abdullah
  - Supreeth Rudrappa
  - Amanda Gates
  - Jonathan Lewis
  - Iskandar Idris
  - Joseph J Bass
  - Hannah Crossland
  - Daniel J Wilkinson
  - Min Tian
  - Deborah S Hustead
  - Geraldine E Baggs
  - Suzette L Pereira
  - Bethan E Phillips
  - Philip J Atherton
- PubMed: 42124050
- DOI: 10.3390/nu18091449
1 Insight on
- Increased Muscle Protein Synthesis
- High evidence
- Rigorous Journal
Therapeutic Outcomes of Aloe vera Gel Compared with Triamcinolone Acetonide in Minor Aphthous Stomatitis.
- 2026-04-30
- RCT · n = 60
- Nigerian journal of clinical practice 29(4)
- - Bhavna
  - S Anand
  - D Jyoti
  - Shalini
  - J Lakshmi
- PubMed: 42085084
- DOI: 10.4103/njcp.njcp_767_25
2 Insights on
- Reduced Pain Severity
- Improved Oral Mucositis Healing
- High evidence
Explore the Optimal Treatment Regimen Across Combinations of Variate Protein Sources and Exercise Modalities and Its Associated Factors in Older Adults: A Network Meta-Analysis and Meta-Regression of Randomized Controlled Trials.
- 2026-04-29
- Meta-Analysis · n = 980
- Nutrients 18(9)
- - Che-Li Lin
  - Shih-Wei Huang
  - Hung-Chou Chen
  - Mao-Hua Huang
  - Tsan-Hon Liou
  - Chun-De Liao
- PubMed: 42124009
- DOI: 10.3390/nu18091409
6 Insights on
- High evidence
- Rigorous Journal
Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels -A Narrative Review.
- 2026-04-29
- Review
- Dermatology and therapy 16(6)
- - Priscila Arbex
  - Edwin D Lephart
- PubMed: 42056376
- DOI: 10.1007/s13555-026-01731-z
4 Insights on
- Low evidence
Randomized clinical trial comparing intra-articular injection of bone marrow aspirate clot and bone marrow aspirate concentrate in grade 3 and 4 knee osteoarthritis.
- 2026-04-29
- RCT
- Stem cell research & therapy 17(1)
- - José Fábio Lana
  - Luyddy Pires
  - Alex Macedo
  - Sérgio Mainine
  - Tomas Mosaner
  - Daniel de Moraes Ferreira Jorge
  - Gabriel Azzini
  - Lucas Furtado da Fonseca
  - Claudia Herrera Tambeli
  - Marco Antônio Percope de Andrade
- PubMed: 42057095
- DOI: 10.1186/s13287-026-05041-1
1 Insight on
- Improved Quality of Life
- High evidence
Vitamin K Biochemistry and Pharmacokinetics: The Basis of Late Vitamin K Deficiency Intracranial Bleeding in Early Infancy.
- 2026-04-29
- Review
- International journal of molecular sciences 27(9)
- - Serafina Perrone
  - Virginia Beretta
  - Vincenzo Raitano
  - Liana Cerioni
  - Silvia Carloni
- PubMed: 42123580
- DOI: 10.3390/ijms27094000
1 Insight on
- Reduced Intracranial Hemorrhage
- Moderate evidence
- Rigorous Journal
Quantum theories of consciousness: a critical review of feasibility, philosophical sufficiency, and empirical testability.
- 2026-04-29
- Review
- Frontiers in psychology 17
- - Xun Ma
  - Aoping Wang
- PubMed: 42137085
- DOI: 10.3389/fpsyg.2026.1730965
2 Insights on
- Reduced Hemoglobin A1c
- Reduced Fasting Blood Glucose Levels
- Low evidence
Clinical efficacy and patient-reported outcomes of coconut oil as adjunctive periodontitis treatment: triple-blinded pilot randomized trial.
- 2026-04-29
- RCT
- BMC oral health 26(1)
- - Simón Pardiñas López
  - Ismael Khouly
  - Fabiana Aellos
  - Karol Apaza Alccayhuaman
  - Silvia María Díaz Prado
- PubMed: 42057009
- DOI: 10.1186/s12903-026-08411-6
8 Insights on
- High evidence
The effect of dietary nitrate on weight management: a systematic review and meta-analysis.
- 2026-04-28
- Meta-Analysis · n = 199
- Frontiers in public health 14
- - Wenjun Cai
  - Peng Wei
  - Fan Yang
  - Lin Shu
  - Yongyao Du
  - Huirong Feng
  - Jiaojiao Shi
  - Chao Kang
  - Xiaoli Peng
- PubMed: 42130877
- DOI: 10.3389/fpubh.2026.1798811
6 Insights on
- High evidence
The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis.
- 2026-04-28
- Meta-Analysis · n = 13
- Nutrients 18(9)
- - Yung-Fang Hsiao
  - Zhongqi Fan
  - Yueh-Yin Fan
  - Mei Chung
- PubMed: 42123986
- DOI: 10.3390/nu18091385
4 Insights on
- High evidence
- Rigorous Journal
The Efficacy of Probiotics in Treating Upper Respiratory Tract Infections, Allergic Rhinitis, and Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis.
- 2026-04-28
- Review
- Microorganisms 14(5)
- - Arezki Azzi
  - Assaf S Alotaibi
  - Muath S Alamri
  - Mohammed A Al-Dosari
  - Faris M Al Murdhi
  - Mohammed N Alatyani
  - Saad M Alnojaim
  - Mohammed A Alrufayyiq
  - Mohammed O Altowaijri
- PubMed: 42197372
- DOI: 10.3390/microorganisms14050986
2 Insights on
- Reduced Antibiotic Use
- Reduced Symptom Duration
- Low evidence
Efficacy and Safety of Limosilactobacillus reuteri DSM 17938 in Infantile Colic: A Narrative Review From Pathogenesis to Clinical Practice.
- 2026-04-27
- Review
- Cureus 18(4)
- - Kimberly Carvajal Méndez
  - Ana Gabriela Álvarez Barrientos
  - Freddy Gutiérrez Rivera
  - Daniel Aragón Leiva
  - Dennis Ulate Fuentes
- PubMed: 42211616
- DOI: 10.7759/cureus.107824
1 Insight on
- Reduced Crying Time
- Low evidence
Triphala as a Topical Agent in Gynaecological Disorders: A Comprehensive Review of Its Pharmacological Actions and Applications.
- 2026-04-27
- Review
- Cureus 18(4)
- - Anita
  - Latika Kundra
  - Poonam Verma
  - Nidhi Tahlan
- PubMed: 42220723
- DOI: 10.7759/cureus.107796
1 Insight on
- Increased Vaginal Lactobacilli Levels
- Low evidence
Curcumin Supplementation Reduces Inflammation, Neutrophil-to-Lymphocyte Ratio (NLR), and Antioxidant Status in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
- 2026-04-27
- RCT · n = 114
- International journal of molecular sciences 27(9)
- - Metha Yaikwawong
  - Khanittha Kamdee
  - Somlak Chuengsamarn
- PubMed: 42123439
- DOI: 10.3390/ijms27093854
8 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
The protective effect of probiotics on intestinal mucosal injury and dysbiosis in infants with congenital heart disease undergoing cardiopulmonary bypass.
- 2026-04-24
- RCT
- Frontiers in immunology 17
- - Zhixuan Zhang
  - Xiaoxu Liu
  - Zhaocong Yang
  - Lan Jiang
  - Chengbin Tang
  - Xuming Mo
- PubMed: 42112337
- DOI: 10.3389/fimmu.2026.1759934
7 Insights on
- High evidence
Comparative Evaluation of Vitamin C and Injectable Platelet-rich Fibrin in the Management of Thin Gingival Phenotype: A Split-mouth Randomized Clinical Trial.
- 2026-04-24
- RCT
- The journal of contemporary dental practice 27(2)
- - Noha M Abdelhay
  - Manar T Elzanaty
  - Riham O Ibrahim
- PubMed: 42145166
- DOI: 10.5005/jp-journals-10024-4022
5 Insights on
- High evidence
Trace Elements and Depressive Symptoms in Coronary Artery Disease: A Systematic Review of Sparse and Predominantly Indirect Evidence.
- 2026-04-24
- Systematic Review
- International journal of molecular sciences 27(9)
- - Jakub Marek Baran
  - Zuzanna Waszak
  - Joanna Jarzębska
  - Damian Grusiecki
  - Maja Śmigielska
  - Wacław Kochman
  - Ewelina A Dziedzic
- PubMed: 42123390
- DOI: 10.3390/ijms27093805
1 Insight on
- Reduced Depression Symptoms
- High evidence
- Rigorous Journal
A randomized controlled trial of L-taurine for fatigue in decompensated cirrhosis.
- 2026-04-24
- RCT · n = 161
- Hepatology communications 10(5)
- - Swarup Sasidharan
  - Cyriac Abby Philips
  - Ajit Tharakan
  - Rizwan Ahamed
  - Tharun Tom Oommen
  - John Menachery
  - Rosh Varghese
  - Philip Augustine
- PubMed: 42043864
- DOI: 10.1097/hc9.0000000000000938
3 Insights on
- High evidence
- Large Human Trial
The Assessment of Multidimensional Clinical, Biological and Patient-Reported Outcomes to Evaluate the Efficacy of Add-On Lactobacillus rhamnosus GG Supplementation in Mild Ulcerative Colitis: A Randomized Pilot Trial.
- 2026-04-23
- RCT
- Nutrients 18(9)
- - Paola Maragno
  - Chiara Amoroso
  - Simone Conforti
  - Marco Michelon
  - Ivanna Honcharyuk
  - Clorinda Ciafardini
  - Daniele Noviello
  - Francesco Strati
  - Flavio Caprioli
  - Federica Facciotti
  - Maurizio Vecchi
- PubMed: 42123931
- DOI: 10.3390/nu18091329
5 Insights on
- High evidence
- Rigorous Journal
Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes.
- 2026-04-23
- RCT · n = 2,098
- JAMA network open 9(4)
- - Bess Dawson-Hughes
  - Gordon S Huggins
  - Jason Nelson
  - Ellen Vickery
  - Sarah N Powers
  - Anastassios G Pittas
- PubMed: 42024385
- DOI: 10.1001/jamanetworkopen.2026.7332
1 Insight on
- Reduced Risk of Diabetes
- High evidence
- Large Human Trial
- Rigorous Journal
Effects of peppermint (Mentha x piperita L.) oil on cardiometabolic outcomes in patients with pre- and stage 1 hypertension: A placebo randomized controlled trial.
- 2026-04-23
- RCT · n = 40
- PloS one 21(4)
- - Jonathan Sinclair
  - Benjamin Sant
  - XuanYi Du
  - Gareth Shadwell
  - Stephanie Dillon
  - Bobbie Butters
  - Lindsay Bottoms
- PubMed: 42024666
- DOI: 10.1371/journal.pone.0344538
7 Insights on
- High evidence
Effects of Combined Caffeine and Rhodiola rosea Supplementation on Repeated Aerial Duel Performance and Neck Neuromuscular Function in Soccer Players.
- 2026-04-23
- RCT
- Nutrients 18(9)
- - Yue Dou
  - Ziyi Feng
  - Hengquan Xu
  - Hexin Ma
  - Yuewei Jiang
  - Xinping Lyu
  - Bolin Han
  - Shuning Liu
  - Chang Liu
  - Dingmeng Ren
- PubMed: 42123940
- DOI: 10.3390/nu18091339
7 Insights on
- High evidence
- Rigorous Journal
The Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiae.
- 2026-04-23
- Traffic (Copenhagen, Denmark) 27(2)
- - Paul Rosas-Santiago
  - Jorge Luis Ruiz Salas
  - Elizabeth Cordoba
  - Francisco Vera-López Portillo
  - Prisciluis Caheri Salas-Navarrete
  - Jaime Arturo Pimentel Cabrera
  - Alfredo Martínez
  - Nayeli Imelda Roldan Ramírez
  - Dieter Chavelas Hernández
  - Andrés Saralegui-Amaro
  - Martha Calahorra
  - Hana Sychrová
  - Olga Zimmermannová
- PubMed: 42026727
- DOI: 10.1111/tra.70035
2 Insights on
- Improved Stress Tolerance
- Impaired Vacuolar Function
- Low evidence