Best Supplements for Improved Blood Lipid Profile
Ranked by research evidence. Compare 77 supplements across 95 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, all reported beneficial effects of Lactobacillus reuteri NCIMB 30242 on blood lipid profiles, with effect sizes ranging from small to moderate. The highest-quality evidence, a randomized controlled trial in hypercholesterolemic adults (n=127), showed a small but statistically significant reduction in LDL-C/HDL-C ratio (-13.39%) and apoB-100/apoA-1 ratio (-9.00%). The predominant effect size across studies is moderate, though the evidence base is small and preliminary.
Product matchLife Extension — FLORASSIST Probiotic Heart Health2,500,000,000 CFU · $23.99 · ★4.6 (406) - Low evidence3 studies
Across 3 studies, 2 reported beneficial small-sized effects and 1 reported a neutral effect. Both beneficial findings were statistically significant. The only study with a reported duration (112 days, ~16 weeks) showed a neutral effect. The evidence base is too small and mixed to draw firm conclusions, with no clear dose or form data available; effects were observed in clinical populations with specific conditions (hypertensive obese OSA patients, women with breast cancer, MASLD patients).
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208) - Low evidence3 studies
Across 3 studies, 2 reported neutral effects with small effect sizes and 1 reported beneficial moderate-sized effects on lipid profiles. No statistically significant findings were observed. The evidence is mixed and preliminary, with no consistent doses or forms reported.
- LowLactobacillus reuteri NCIMB 30242Across 3 studies, all reported beneficial effects of Lactobacillus reuteri NCIMB 30242 on blood lipid profiles, with effect sizes ranging from small to moderate. The highest-quality evidence, a randomized controlled trial in hypercholesterolemic adults (n=127), showed a small but statistically significant reduction in LDL-C/HDL-C ratio (-13.39%) and apoB-100/apoA-1 ratio (-9.00%). The predominant effect size across studies is moderate, though the evidence base is small and preliminary.3 beneficial3 studies
- LowVitamin DAcross 3 studies, 2 reported beneficial small-sized effects and 1 reported a neutral effect. Both beneficial findings were statistically significant. The only study with a reported duration (112 days, ~16 weeks) showed a neutral effect. The evidence base is too small and mixed to draw firm conclusions, with no clear dose or form data available; effects were observed in clinical populations with specific conditions (hypertensive obese OSA patients, women with breast cancer, MASLD patients).2 beneficial1 neutral3 studies
- LowOlive OilAcross 3 studies, 2 reported neutral effects with small effect sizes and 1 reported beneficial moderate-sized effects on lipid profiles. No statistically significant findings were observed. The evidence is mixed and preliminary, with no consistent doses or forms reported.1 beneficial2 neutral3 studies