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Berberine

Safety profile

4 studies reporting safety data

Across 4 clinical studies, no specific adverse events were reported at increased risk with berberine. One study found no statistically significant difference in overall tolerability compared to control (RR = 0.75, 95% CI [0.42, 1.33]). Berberine was generally described as well tolerated, with gastrointestinal symptoms being the most frequently mentioned adverse effect, though these attenuated during the first month of treatment. No serious adverse events were reported.

Caveats: Evidence is limited to 4 clinical studies; the absence of reported adverse events does not establish safety, and the studies may not have been powered to detect rare or long-term adverse events. Most studies were short-term, and safety beyond the treatment period or in specific populations (e.g., pregnant women, children) is not characterized.

  • Berberine with Oregon Grape

    By Zhou Nutrition

    4.7 (759 reviews)
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    $16.37
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  • Berberine Phytosome

    By Enzymedica

    4.8 (114 reviews)
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    $22.87
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    $18.56
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  • Berberine Phytosome

    By Solaray

    4.6 (18 reviews)
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    $20.15
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    $25.33
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  • Berberine Advanced Enhanced Absorption

    By Swanson

    4.8 (200 reviews)
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    $19.99
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  • Goldenseal Root

    By Nature's Way

    4.8 (375 reviews)
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    $25.05
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  • Essentials

    By Allmax

    5 (1 reviews)
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    $14.99
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