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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Berberine and Reduced Low-Density Lipoprotein Level

Doses used in studies

g/day: 1 (median 1, IQR 1–1) — 1 study

Time to effect

Median: 6 months · IQR 6 months–6 months · Range 6 months–6 months — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
The incidence of adverse events was similar between study arms.
from: Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized

2 of 2 papersPopulation:

Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial.
- 2026-01-02
- RCT
- JAMA network open 9(1)
- - Lubi Lei
  - Bin Wang
  - Lingshan Zhao
  - Jingkuo Li
  - Xiaofang Yan
  - Jiandong Jiang
  - Lulu Wang
  - Gang Ren
  - Yinchu Li
  - Xiaoguang Cheng
  - Xiaoyan Yan
  - Yidan Zhu
  - Yuanlin Guo
  - Hui Zhong
  - Haibo Zhang
  - Jing Li
- PubMed: 41543854
- DOI: 10.1001/jamanetworkopen.2025.54152
5 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Rigorous Journal
- Clinical
Berberine was associated with larger reductions in low-density lipoprotein cholesterol (-7.72 [95% CI, -13.13 to -1.93] mg/dL)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
1 g/d
The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis.
- 2025-07-30
- Meta-Analysis
- Systematic reviews 14(1)
- - Chongxiang Xue
  - Ying Chen
  - Cheng Tang
  - Linhua Zhao
  - Xiaolin Tong
  - Han Wang
- PubMed: 40739586
- DOI: 10.1186/s13643-025-02914-z
4 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
GQD and berberine intervention could effectively reduce total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL-c) and increase high-density lipoprotein (HDL-c).
Effect
Beneficial
Effect size
Small
Significant
Yes