Best Supplements for Reduced Low-Density Lipoprotein Level
Ranked by research evidence. Compare 63 supplements across 78 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, 3 reported beneficial small-sized effects of L-carnitine supplementation on reducing low-density lipoprotein (LDL) levels, while 1 study found neutral effects. The most robust evidence comes from a high-quality meta-analysis in adults with type 2 diabetes (n=2041) showing a small reduction in LDL (MD: -0.11 mmol/L). Doses ranged from 1 g/day to >2 g/day, and effects were consistently small in magnitude.
Dose: 1–2+ g/day - Low evidence3 studies
Artichoke supplementation shows moderate evidence for a small to moderate beneficial effect on reducing LDL-C levels, based on 3 studies. All 3 studies reported significant beneficial findings, with one meta-analysis reporting an average reduction of ~17.5 mg/dL. Effects were observed in clinical populations (bariatric surgery candidates and NAFLD patients) over a median study duration of 42 days, though dosing information was limited.
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects of turmeric/curcumin on reducing low-density lipoprotein (LDL) levels, with effect sizes ranging from small to moderate. The median study duration was 90 days (based on 1 study). The most studied population was clinical patients with metabolic conditions (e.g., type 2 diabetes, metabolic syndrome, hemodialysis patients).
- ModerateL-CarnitineAcross 4 studies, 3 reported beneficial small-sized effects of L-carnitine supplementation on reducing low-density lipoprotein (LDL) levels, while 1 study found neutral effects. The most robust evidence comes from a high-quality meta-analysis in adults with type 2 diabetes (n=2041) showing a small reduction in LDL (MD: -0.11 mmol/L). Doses ranged from 1 g/day to >2 g/day, and effects were consistently small in magnitude. · Dose: 1–2+ g/day3 beneficial1 neutral4 studies
- LowArtichokeArtichoke supplementation shows moderate evidence for a small to moderate beneficial effect on reducing LDL-C levels, based on 3 studies. All 3 studies reported significant beneficial findings, with one meta-analysis reporting an average reduction of ~17.5 mg/dL. Effects were observed in clinical populations (bariatric surgery candidates and NAFLD patients) over a median study duration of 42 days, though dosing information was limited.3 beneficial3 studies
- LowTurmericAcross 3 studies, 2 reported beneficial effects of turmeric/curcumin on reducing low-density lipoprotein (LDL) levels, with effect sizes ranging from small to moderate. The median study duration was 90 days (based on 1 study). The most studied population was clinical patients with metabolic conditions (e.g., type 2 diabetes, metabolic syndrome, hemodialysis patients).2 beneficial1 neutral3 studies