Research synthesisHigh evidenceMixed effect size5 studies · 5 beneficial · 0 neutral · 0 harmful
Across 5 studies, all reported beneficial effects of artichoke on reducing low-density lipoprotein (LDL) cholesterol, with statistically significant findings in every case. Effect sizes were mixed (small to moderate), and the most-studied dose was 600 mg daily of artichoke leaf extract. Effects were typically observed at 6–8 weeks (median study duration 51 days), primarily in clinical populations with non-alcoholic fatty liver disease (NAFLD) or undergoing bariatric surgery.
- Effective dose range: 600 mg daily
- Studied populations: people with non-alcoholic fatty liver disease (NAFLD), bariatric surgery candidates
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies focused on clinical populations with NAFLD or metabolic conditions, so benefits may not generalize to healthy adults. Study durations were relatively short (42–60 days), and long-term efficacy remains unclear.
Generated Jun 15, 2026