Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Artichoke

What does the research say about Artichoke?

3 health outcomes synthesised

Artichoke leaf extract has been investigated in human clinical trials primarily for its effects on blood lipid profiles, with research covering three health outcomes: reduced LDL cholesterol, reduced triglyceride levels, and reduced total cholesterol. The strongest evidence comes from five studies examining LDL cholesterol reduction, all of which reported statistically significant benefits, most commonly using a dose of 600 mg daily. The research has predominantly focused on clinical populations, such as people with non-alcoholic fatty liver disease (NAFLD) or those preparing for bariatric surgery, rather than healthy adults.

Strongest evidence: The most consistently studied outcome is reduced low-density lipoprotein (LDL) cholesterol, backed by 5 studies with high evidence strength, all showing statistically significant beneficial effects. The typical dose was 600 mg daily of artichoke leaf extract, with effects observed after 6–8 weeks (median 51 days). For reduced triglyceride levels, 4 studies (moderate evidence strength) all reported beneficial effects, with small effect sizes at doses ranging from 600 to 1800 mg daily over a median of 72 days. For reduced total cholesterol, 3 studies (moderate evidence strength) showed moderate effects, including a meta-analysis of 702 subjects reporting a mean decrease of 17.6 mg/dL in total cholesterol.

Mixed or weaker evidence: No outcomes with low or very low evidence strength were identified among the synthesized data. However, the effect sizes for triglycerides were small, and for LDL cholesterol they were mixed (small to moderate), suggesting that the magnitude of benefit may vary across individuals and study conditions.

Effective dose patterns: Across all three outcomes, a dose of 600 mg daily of artichoke leaf extract appears most consistently studied and effective. For triglycerides, higher doses up to 1800 mg daily were also used, though optimal dosing remains to be established.

Population insights: The research overwhelmingly focused on clinical populations — specifically individuals with non-alcoholic fatty liver disease (NAFLD), metabolic syndrome, and pre-bariatric surgery candidates. There is limited evidence on whether benefits generalize to healthy adults or to populations without elevated lipid levels.

Notable caveats: The available literature is subject to publication bias, as null-result studies are less likely to be published or indexed. Study durations were short (42–72 days), with no long-term efficacy data. Generalizability to healthy individuals is unclear since the evidence is drawn from patients with metabolic conditions.

Frequently asked

  • What is Artichoke good for according to research?
    Research on artichoke leaf extract has focused on three lipid-related outcomes: reducing LDL cholesterol, reducing triglyceride levels, and reducing total cholesterol. Across all three areas, studies have consistently reported beneficial effects, with the strongest evidence supporting a reduction in LDL cholesterol (5 studies, all statistically significant).
  • What dose of Artichoke is typically used in studies?
    The most commonly studied dose across all outcomes is 600 mg daily of artichoke leaf extract. For triglyceride reduction, studies have used doses ranging from 600 to 1800 mg daily, though the optimal dose has not been firmly established.
  • Who benefits most from Artichoke?
    The existing research primarily involved clinical populations, specifically people with non-alcoholic fatty liver disease (NAFLD), metabolic syndrome, and candidates for bariatric surgery. It remains unclear whether healthy adults without elevated lipid levels would experience similar benefits.
  • Are there caveats or limitations in the research on Artichoke?
    Yes, important caveats include potential publication bias — null-result studies are less likely to be published. Study durations were short (42 to 72 days), and no long-term safety or efficacy data are available. The findings may not generalize to healthy individuals, as most participants had metabolic conditions.
  • Does Artichoke help reduce LDL cholesterol?
    Yes, all 5 studies on LDL cholesterol reduction reported statistically significant beneficial effects, with small to moderate effect sizes. The strongest evidence used 600 mg daily of artichoke leaf extract, with benefits typically seen after 6 to 8 weeks of supplementation.
  • Does Artichoke help lower triglyceride levels?
    Evidence from 4 studies suggests that artichoke supplementation can reduce triglyceride levels, with all studies showing statistically significant results. The effect sizes were generally small, and the most effective dose appears to be in the range of 600 to 1800 mg daily over at least 8 weeks.

  • Artichoke

    By Best Naturals

    4.8 (100 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $17.99
    		In
    iHerb
    $17.20
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • Artichoke Extract

    By Nutricost

    4.9 (253 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $16.95
    		In
    iHerb
    $16.95
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • Lipid

    By Revive

    3.7 (6 reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $54.99
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • Artichoke Extract 500

    By Source Naturals

    4.8 (547 reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $29.65
    		In
    iHerb
    $24.65
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • Artichoke

    By Jarrow Formulas

    4.9 (8.4K reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $25.74
    		In
    iHerb
    $28.49
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • Artichoke

    By Seagate

    4.8 (2.4K reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $13.15
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out
Back to top