Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful
Across all 3 studies, artichoke supplementation consistently shows beneficial moderate-sized effects on reducing total and LDL cholesterol. Effects are observed most clearly in clinical populations (e.g., NAFLD, pre-bariatric surgery patients) and after 6-8 weeks of use, with the strongest evidence from a meta-analysis of 702 subjects reporting a decrease of 17.6 mg/dL in total cholesterol.
- Effective dose range: 600 mg daily
- Studied populations: people with non-alcoholic fatty liver disease (NAFLD), pre-bariatric surgery candidates
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The effect size was smaller in one study that enrolled pre-bariatric patients (small effect) compared to the meta-analysis and NAFLD trial, suggesting benefit may vary by population and baseline cholesterol levels.
Generated Jun 15, 2026