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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Artichoke and Reduced Aspartate Aminotransferase Level

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 8.6 weeks · IQR 8.6 weeks–8.6 weeks · Range 8.6 weeks–8.6 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
Ninety patients completed the study (49 ALE and 41 placebo) with no side effects reported.
from: Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-bl

2 of 2 papers

Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial.
- 2018-03-09
- RCT · n = 100
- Phytotherapy research : PTR 32(7)
- - Yunes Panahi
  - Parisa Kianpour
  - Reza Mohtashami
  - Stephen L Atkin
  - Alexandra E Butler
  - Ramezan Jafari
  - Roghayeh Badeli
  - Amirhossein Sahebkar
- PubMed: 29520889
- DOI: 10.1002/ptr.6073
12 Insights on
- Reduced Aspartate Aminotransferase Level
- High evidence
- Large Human Trial
- Clinical
reduction in serum AST (p < .001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
600 mg daily
Effects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of randomized controlled trials.
- 2024-06-17
- Review · n = 2,509
- Phytotherapy research : PTR 38(7)
- - Hongshuai Liu
  - Yufei Li
  - Yan Jin
  - Xin Li
  - Dongxian Wang
  - Xiaowen Yu
  - Zhenyuan Jiang
  - Guoliang Yin
  - Suwen Chen
  - Xin Zhang
  - Decheng Meng
  - Wenfei Yu
  - Wenyin Jiang
  - Fengxia Zhang
- PubMed: 38886838
- DOI: 10.1002/ptr.8182
7 Insights on
- Reduced Aspartate Aminotransferase Level
- High evidence
- Clinical
artichoke leaf extract confers a relative advantage in reducing the aspartate aminotransferase (AST) levels (SUCRA: 99.1%)
Effect
Beneficial
Effect size
Small
Significant
Yes