Best Supplements for Reduced Aspartate Aminotransferase Level
Ranked by research evidence. Compare 15 supplements across 22 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies on vitamin E for reducing aspartate aminotransferase (AST) levels, 3 reported beneficial effects (predominantly small in magnitude) and 1 was neutral. Two of the 4 findings were statistically significant. The evidence comes almost entirely from clinical populations with non-alcoholic fatty liver disease (NAFLD) or related steatotic liver conditions, with a median study duration of 72 days (approximately 10 weeks), suggesting effects typically observed at 8-12 weeks. Doses ranged from 298 to 1000 IU/day, though not all studies specified dose.
Dose: 298 to 1000 IU/day - Low evidence3 studies
Across all 3 studies, red grape supplementation showed beneficial effects on reducing aspartate aminotransferase (AST) levels, with predominantly small-to-moderate effect sizes. Doses ranged from 100–520 mg/day of grape seed extract over 28–60 days, with effects observed primarily in clinical populations with NAFLD or thalassemia. The evidence is promising but based on a small number of studies.
Dose: 100–520 mg/day of grape seed extract
- ModerateVitamin EAcross 4 studies on vitamin E for reducing aspartate aminotransferase (AST) levels, 3 reported beneficial effects (predominantly small in magnitude) and 1 was neutral. Two of the 4 findings were statistically significant. The evidence comes almost entirely from clinical populations with non-alcoholic fatty liver disease (NAFLD) or related steatotic liver conditions, with a median study duration of 72 days (approximately 10 weeks), suggesting effects typically observed at 8-12 weeks. Doses ranged from 298 to 1000 IU/day, though not all studies specified dose. · Dose: 298 to 1000 IU/day3 beneficial1 neutral4 studies
- LowRed GrapeAcross all 3 studies, red grape supplementation showed beneficial effects on reducing aspartate aminotransferase (AST) levels, with predominantly small-to-moderate effect sizes. Doses ranged from 100–520 mg/day of grape seed extract over 28–60 days, with effects observed primarily in clinical populations with NAFLD or thalassemia. The evidence is promising but based on a small number of studies. · Dose: 100–520 mg/day of grape seed extract3 beneficial3 studies