Best Supplements for Reduced Aspartate Aminotransferase Level
Ranked by research evidence. Compare 28 supplements across 48 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence8 studies
Across 8 studies, 5 reported beneficial effects of thistle (silymarin) on reducing aspartate aminotransferase (AST) levels, with effect sizes ranging from small to large (predominantly large). The evidence is strongest in clinical populations with liver conditions (NAFLD, ALD, hepatitis) and metabolic syndrome, with effects typically observed at 12 weeks or longer. Doses ranged from 420 mg/day (140 mg three times daily) to 800 mg/day, though many studies did not specify dosing.
Dose: 140 mg three times daily to 800 mg/day - Moderate evidence5 studies
Across 5 studies, 3 reported beneficial small-to-moderate effects of vitamin E on reducing aspartate aminotransferase (AST) levels, while 2 found neutral effects. The predominant effect size is small. Evidence primarily comes from patients with NAFLD/MASLD, with doses ranging from 300 to 1000 IU/day. Median study duration was 72 days, suggesting effects typically observed at 8–12 weeks.
Dose: 300–1000 IU/day - Moderate evidence4 studies
Across 4 studies, 3 reported beneficial effects of red grape or its extracts on reducing aspartate aminotransferase (AST) levels, with one neutral finding. The predominant effect size was small, though one moderate effect was observed. Effects were seen in clinical populations, primarily individuals with NAFLD or thalassemia, over a median duration of 44 days (approximately 6 weeks).
- ModerateThistleAcross 8 studies, 5 reported beneficial effects of thistle (silymarin) on reducing aspartate aminotransferase (AST) levels, with effect sizes ranging from small to large (predominantly large). The evidence is strongest in clinical populations with liver conditions (NAFLD, ALD, hepatitis) and metabolic syndrome, with effects typically observed at 12 weeks or longer. Doses ranged from 420 mg/day (140 mg three times daily) to 800 mg/day, though many studies did not specify dosing. · Dose: 140 mg three times daily to 800 mg/day5 beneficial3 neutral8 studies
- ModerateVitamin EAcross 5 studies, 3 reported beneficial small-to-moderate effects of vitamin E on reducing aspartate aminotransferase (AST) levels, while 2 found neutral effects. The predominant effect size is small. Evidence primarily comes from patients with NAFLD/MASLD, with doses ranging from 300 to 1000 IU/day. Median study duration was 72 days, suggesting effects typically observed at 8–12 weeks. · Dose: 300–1000 IU/day3 beneficial2 neutral5 studies
- ModerateRed GrapeAcross 4 studies, 3 reported beneficial effects of red grape or its extracts on reducing aspartate aminotransferase (AST) levels, with one neutral finding. The predominant effect size was small, though one moderate effect was observed. Effects were seen in clinical populations, primarily individuals with NAFLD or thalassemia, over a median duration of 44 days (approximately 6 weeks).3 beneficial1 neutral4 studies
- LowBlack CuminAcross 3 studies, 1 (a 2025 meta-analysis of 82 RCTs) reported a small beneficial effect of black cumin supplementation on reducing aspartate aminotransferase (AST) levels, while 2 studies (including another meta-analysis) found no significant effect. Effect sizes were predominantly small. The only positive result came from a large meta-analysis with a wide dose range (200–4600 mg/day), but the overall evidence base is limited.1 beneficial2 neutral3 studies