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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Thistle

Safety profile

4 studies reporting safety data

Across 4 clinical studies, no specific adverse events were quantitatively reported for thistle (silymarin). It was described as well tolerated in multiple studies, with minimal adverse effects such as mild gastrointestinal reactions and insomnia in one study. No significant differences in safety markers were observed.

Caveats: Evidence is limited to a small number of studies (4), most of which were not primarily designed to assess safety. Long-term safety and effects in specific populations (e.g., pregnant women) are not established.

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