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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Thistle and Reduced Diastolic Blood Pressure

Doses used in studies

g/day: 0.8 (median 0.8, IQR 0.8–0.8) — 1 study
mg/day: 103.2 (median 103.2, IQR 103.2–103.2) — 1 study

Time to effect

Median: 4.3 months · IQR 3.7 months–5 months · Range 3 months–5.6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
No adverse effects were found in volunteers using silymarin (0.8 g/day), silymarin+yacon (0.8+2.4 g/day) and silymarin+maca (0.6+0.2 g/day).
from: Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin

2 of 2 papers

Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, placebo-controlled trial.
- 2024-08-03
- RCT · n = 83
- Lipids in health and disease 23(1)
- - Yufeng Jin
  - Xin Wang
  - Ke Chen
  - Yu Chen
  - Lixin Zhou
  - Yupeng Zeng
  - Yuqing Zhou
  - Zhijun Pan
  - Di Wang
  - Zhongxia Li
  - Yongqian Liang
  - Wenhua Ling
  - Dan Li
- PubMed: 39097726
- DOI: 10.1186/s12944-024-02220-y
19 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
- Clinical
physical measurements (DBP, SBP, BMI, WHR, BF%, and BMR)
Effect
Neutral
Effect size
Small
Significant
No
Dose
103.2 mg/d
Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment.
- 2008-03
- RCT
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(3)
- - Katerina Valentová
  - David Stejskal
  - Josef Bartek
  - Svatava Dvorácková
  - Vladimír Kren
  - Jitka Ulrichová
  - Vilím Simánek
- PubMed: 18054420
- DOI: 10.1016/j.fct.2007.10.031
3 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
- Clinical
A moderate AST level and diastolic blood pressure increase was found in volunteers using maca (0.6 g/day).
Effect
Harmful
Effect size
Moderate
Significant
Yes
Dose
0.6 g/day