Thistle and Reduced Hemoglobin A1c

• Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.

  • 2025-05-29
  • Systematic Review · n = 337
  • Phytotherapy research : PTR 39(12)
  • • Runyu Miao
    • Boxun Zhang
    • Danni Zhou
    • Mengjiao Kang
    • Jiaxing Tian
    • Linhua Zhao
    • Xiaolin Tong

  • PubMed: 40439602
  • DOI: 10.1002/ptr.8431

  12 Insights on

  • Reduced Hemoglobin A1c

  • High evidence
  • Clinical

  silymarin significantly improved … hemoglobin A1c (HbA1c) (P < 0.05). For HbA1c, silymarin was more effective than resveratrol (MD -2.08, 95%Cl -3.50 to -0.72) (P < 0.05)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review.

  • 2024-05-27
  • Systematic Review
  • Naunyn-Schmiedeberg's archives of pharmacology 397(10)
  • • Parisa Zare Mehrjerdi
    • Sara Asadi
    • Elham Ehsani
    • Vahid Reza Askari
    • Vafa Baradaran Rahimi

  • PubMed: 38801454
  • DOI: 10.1007/s00210-024-03172-x

  15 Insights on

  • Reduced Hemoglobin A1c

  • High evidence

  increasing glycosylated hemoglobin (HbA1C) and antioxidative marker levels

  Effect

  Harmful

  Effect size

  Small

  Significant

  Yes