Thistle and Reduced Aspartate Aminotransferase Level

• Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review.

  • 2025-02-04
  • Systematic Review · n = 221
  • Frontiers in pharmacology 16
  • • Yan Wang
    • Wenmin Yang
    • Yuan Yang
    • Xingning Liu
    • Lanfen Peng
    • Qi Huang
    • Kongli Fan
    • Rui Hu
    • Jinyu Yi
    • Xin Zhong
    • Jing Li
    • Jialing Sun
    • Xiaozhou Zhou

  • PubMed: 39968181
  • DOI: 10.3389/fphar.2025.1516204

  9 Insights on

  • Reduced Aspartate Aminotransferase Level

  • High evidence
  • Clinical

  AST [SMD = -1.56, 95% CI (-2.18, -0.95)]

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.

  • 2026-01-23
  • Clinical Trial · n = 130
  • Frontiers in nutrition 12
  • • Ghanashyam Patel
    • Saumin Shah
    • Christopher R D'Adamo

  • PubMed: 41659807
  • DOI: 10.3389/fnut.2025.1721748

  4 Insights on

  • Reduced Aspartate Aminotransferase Level

  • High evidence
  • Adults

  Mean improvements in ALT, AST, ALP, and GGT were significantly greater with the nutraceutical product than placebo (p ≤ 0.001).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes