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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Artichoke and Reduced Liver Size

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 7.3 weeks · IQR 6.6 weeks–7.9 weeks · Range 6 weeks–8.6 weeks — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
Ninety patients completed the study (49 ALE and 41 placebo) with no side effects reported.
from: Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-bl

2 of 2 papers

Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial.
- 2018-03-09
- RCT · n = 100
- Phytotherapy research : PTR 32(7)
- - Yunes Panahi
  - Parisa Kianpour
  - Reza Mohtashami
  - Stephen L Atkin
  - Alexandra E Butler
  - Ramezan Jafari
  - Roghayeh Badeli
  - Amirhossein Sahebkar
- PubMed: 29520889
- DOI: 10.1002/ptr.6073
12 Insights on
- Reduced Liver Size
- High evidence
- Large Human Trial
- Clinical
reduced … liver size (p < .001)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
600 mg daily
Artichoke leaf extract reduces steatosis and decreases liver size in prebariatric patients: A randomized placebo-controlled pilot trial-The "SteatoChoke-Study".
- 2026-01
- RCT
- Journal of clinical lipidology 20(1)
- - Sebastian Holländer
  - Evelyn Marth
  - Philipp Robert Scherber
  - Antonios Spiliotis
  - Ammar Al-Ali
  - Gereon Gäbelein
  - Matthias Glanemann
- PubMed: 41274796
- DOI: 10.1016/j.jacl.2025.10.063
6 Insights on
- Reduced Liver Size
- High evidence
- Clinical
ALE intake significantly reduced CAP values and liver lobe diameters compared to placebo, indicating decreased steatosis and liver volume.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not stated