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Evidence-Based Supplement Research
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Garlic and Reduced Low-Density Lipoprotein Level

Research synthesisHigh evidenceModerate effect6 studies · 6 beneficial · 0 neutral · 0 harmful

Across 6 studies, all reported beneficial effects of garlic on reducing LDL cholesterol, with effect sizes ranging from small to moderate; the predominant effect size was moderate. The evidence is drawn from meta-analyses and systematic reviews, primarily in clinical populations with metabolic syndrome, dyslipidemia, or hypertension. The median study duration was 56 days, suggesting effects typically observed at 8 weeks.

  • Studied populations: people with metabolic syndrome, dyslipidemia, or hypertension

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies did not specify garlic form or dosage; the only reported dose (2.4 mg) is unusually low and may be a data entry error. One included study focused on HDL rather than LDL, but was categorized under LDL reduction. The meta-analyses may have overlapping primary studies, inflating consistency.

Generated Jul 9, 2026
Doses used in studies
  • mg/day: 2.4 (median 2.4, IQR 2.4–2.4) — 1 study
Time to effect
Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 6 studies
Safety in these studies
6 of 6 papers
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