Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels?

2021-08-04
Current atherosclerosis reports 23(10)
- Arrigo F G Cicero
- Federica Fogacci
- Anca Pantea Stoian
- Michal Vrablik
- Khalid Al Rasadi
- Maciej Banach
- Peter P Toth
- Manfredi Rizzo

PubMed: 34345932
DOI: 10.1007/s11883-021-00955-y

Study Design

Type: Review
Population: subjects affected by mild-to-moderate dyslipidaemia with low cardiovascular risk
Methods: review of available clinical efficacy and safety data related to lipid-lowering nutraceuticals
Funding: Unclear

Purpose of review

The aim of this review is to summarize the available clinical efficacy and safety data related to the most studied and used lipid-lowering nutraceuticals.

Recent findings

A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as red yeast rice, plant sterols and stanols, soluble fibers, berberine, artichoke extracts, bergamot polyphenol fraction, garlic, green tea, and spiruline. No significant safety concern has been raised for the use of such products. Association of more lipid-lowering nutraceuticals and of some nutraceuticals with lipid-lowering drugs has been tested as well. Current evidence suggests that some clinically tested lipid-lowering nutraceuticals could be safely used to improve plasma lipid levels in subjects affected by mild-to-moderate dyslipidaemia with low cardiovascular risk.

Research Insights

Berberine→Reduced Low-Density Lipoprotein Level
A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as ... green tea
Effect
Beneficial
Effect size
Moderate
Bergamot→Reduced Low-Density Lipoprotein Level
A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as ... green tea
Effect
Beneficial
Effect size
Moderate
Garlic→Reduced Low-Density Lipoprotein Level
A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as ... green tea
Effect
Beneficial
Effect size
Moderate
green tea→Reduced Low-Density Lipoprotein Level
A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as ... green tea
Effect
Beneficial
Effect size
Moderate
red yeast rice→Reduced Low-Density Lipoprotein Level
A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as ... green tea
Effect
Beneficial
Effect size
Moderate