Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis.

  • 2018-05
  • Medicine 97(18)
    • Yue-E Sun
    • Weidong Wang
    • Jie Qin

Study Design

Type
Meta-Analysis
Sample size
n = 14
Methods
meta-analysis of 14 eligible papers published from 1981 to 2016 using keywords such as "garlic" and "hypercholesterolemia"

Background

This study aimed to understand the impact of garlic on improving blood lipids using a meta-analysis.

Methods

A literature search of the PubMed, EMBASE, and Cochrane Library databases was performed using keywords such as "garlic" and "hypercholesterolemia," and the deadline "July 14 (th), 2017." After extracting relevant details, each selected literature was evaluated for quality according to the quality evaluation criteria of bias risk recommended by Cochrane Collaboration recommendations and heterogeneity tests were performed. Standardized mean difference (SMD) and 95% confidence interval (CI) were evaluated using R 3.12 software. The publication bias was assessed using Egger method.

Results

A total of 14 eligible papers published from 1981 to 2016 were included. The quality of the literatures was of moderate to high qualities. The values of TC (SMD = -1.26, 95% CI, -1.86 to -0.66), low-density lipoprotein (LDL) (SMD = -1.07, 95% CI, -1.67 to -0.47), and high-density lipoprotein (HDL) (SMD = 0.50, 95% CI, 0.06-0.94) after taking garlic in the experimental group and the control group have statistical significance, while there was no significant difference of TG in the 2 groups (SMD = -0.16, 95% CI, -0.87-0.55). However, the result of HDL was reversed when removed some of the literatures. No significant publication bias among the eligible studies with values of TC (P = .0625), LDL (P = .0770), HDL (P = .2293), and TG (P = .3436).

Conclusion

Garlic can reduce the level of TC and LDL instead of HDL and TG, indicating the ability of anti-hyperlipidemia.

Research Insights

  • Garlic→Reduced Blood Cholesterol

    The values of TC (SMD = -1.26, 95% CI, -1.86 to -0.66) ... after taking garlic in the experimental group and the control group have statistical significance

    Effect
    Beneficial
    Effect size
    Large
  • Garlic→Reduced Low-Density Lipoprotein Level

    high-density lipoprotein (HDL) (SMD = 0.50, 95% CI, 0.06-0.94) after taking garlic in the experimental group and the control group have statistical significance

    Effect
    Beneficial
    Effect size
    Moderate
  • Garlic→Reduced Triglyceride Levels

    there was no significant difference of TG in the 2 groups (SMD = -0.16, 95% CI, -0.87-0.55)

    Effect
    Neutral
    Effect size
    Small
Back to top