Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Berberine and Reduced Waist Circumference

Research synthesisLow evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects of berberine on reducing waist circumference, with effect sizes ranging from small to moderate, while 1 study found a neutral effect. The median study duration was 84 days (12 weeks), suggesting that effects are typically observed after sustained use. The most-studied population included adults with metabolic conditions such as type 2 diabetes and obesity, though dosing information was limited and not consistently reported.

  • Studied populations: adults with type 2 diabetes, adults with obesity

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Dosing information was missing or varied across studies, making it difficult to identify an effective dose range.

Generated Jun 15, 2026
Doses used in studies
  • mg/day: 1,200 (median 1,200, IQR 1,200–1,200) — 1 study
Time to effect
Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 3 studies
Safety in these studies
3 of 3 papers
Back to top