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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Berberine and Reduced Body Weight

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 2 studies

Safety in these studies

gastrointestinal symptomsReported
The most frequent adverse effects in both groups were gastrointestinal symptoms, which attenuated during the first month of treatment.
from: Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, an

2 of 2 papers

The effect of berberine on obesity indices: a systematic review and meta-analysis.
- 2025-11-27
- Meta-Analysis · n = 23
- International journal of obesity (2005) 50(1)
- - Iman Elahi Vahed
  - Erfan Shahir-Roudi
  - Sina Nojumi
  - Samieh Golmohammadi
  - Mehdi Moradi Shahrebabak
  - Niloofar Sharafi Tafreshi Moghadam
  - Amir Sajad Bagheryan
  - Maryam Moftakhar
  - Fateme Shamsipour
  - Mahla Jafari
  - Hossein Soltaninejad
  - Mohammad Rahmanian
- PubMed: 41310257
- DOI: 10.1038/s41366-025-01943-x
4 Insights on
- Reduced Body Weight
- High evidence
- Clinical
Berberine significantly reduced body weight (MD of -0.88 kg, 95% CI: -1.36 to -0.39, p = 0.0003)
Effect
Beneficial
Effect size
Small
Significant
Yes
Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.
- 2024-07-16
- RCT
- Nutrients 16(14)
- - Cindy Bandala
  - Jazmín Carro-Rodríguez
  - Noemí Cárdenas-Rodríguez
  - Itzel Peña-Montero
  - Modesto Gómez-López
  - Ana Paola Hernández-Roldán
  - Juan Carlos Huerta-Cruz
  - Felipe Muñoz-González
  - Iván Ignacio-Mejía
  - Brayan Domínguez
  - Eleazar Lara-Padilla
- PubMed: 39064727
- DOI: 10.3390/nu16142284
7 Insights on
- Reduced Body Weight
- High evidence
- Rigorous Journal
- Clinical
BBR significantly decreased (p < 0.05) body weight, blood pressure and Vis and Ap gene expression and increased Ome
Effect
Beneficial
Effect size
Moderate
Significant
Yes