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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Improved Blood Lipid Profile

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small-sized effects and 1 reported a neutral effect. Both beneficial findings were statistically significant. The only study with a reported duration (112 days, ~16 weeks) showed a neutral effect. The evidence base is too small and mixed to draw firm conclusions, with no clear dose or form data available; effects were observed in clinical populations with specific conditions (hypertensive obese OSA patients, women with breast cancer, MASLD patients).

  • Studied populations: hypertensive obese OSA patients, women with estrogen/progesterone-receptor-positive breast cancer, patients with MASLD

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The only RCT (highest evidence score) showed a neutral effect, while the two beneficial findings come from narrative reviews (lower evidence quality). Effect sizes were consistently small even in beneficial studies.

Generated Jul 12, 2026
Time to effect
Median: 3.7 months · IQR 3.7 months–3.7 months · Range 3.7 months–3.7 months — Reported in 1 of 3 studies
3 of 3 papers
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