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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Improved Blood Lipid Profile

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported small beneficial effects and 1 reported a neutral effect, with 2 of 3 reaching statistical significance. The predominant effect size is small. Median study duration across the one study reporting duration was 112 days (16 weeks). The evidence base is too small to determine a most-studied dose or population with confidence.

  • Studied populations: clinical populations including hypertensive obese OSA patients and women with estrogen/progesterone-receptor-positive breast cancer

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The single highest-quality RCT (evidence score 5) found a neutral effect, while the two narrative reviews (evidence score 2) reported beneficial effects, suggesting the supporting evidence is weaker than the aggregate count implies.

Generated Jun 11, 2026
Time to effect
Median: 3.7 months · IQR 3.7 months–3.7 months · Range 3.7 months–3.7 months — Reported in 1 of 3 studies
3 of 3 papers
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