Best Supplements for Reduced Pro-inflammatory Cytokine Levels
Ranked by research evidence. Compare 27 supplements across 34 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, 3 reported beneficial effects on reducing pro-inflammatory cytokine levels, with effect sizes ranging from moderate to large; one neutral study found a small non-significant effect. The most robust evidence comes from a 12-month RCT in 114 adults with type 2 diabetes using 1500 mg/day curcumin, showing large significant reductions. Most studies focused on clinical populations with metabolic conditions (e.g., type 2 diabetes, NAFLD, metabolic syndrome), but two systematic reviews included turmeric among mixed polyphenol interventions, limiting attribution.
27 supplements
- ModerateTurmericAcross 4 studies, 3 reported beneficial effects on reducing pro-inflammatory cytokine levels, with effect sizes ranging from moderate to large; one neutral study found a small non-significant effect. The most robust evidence comes from a 12-month RCT in 114 adults with type 2 diabetes using 1500 mg/day curcumin, showing large significant reductions. Most studies focused on clinical populations with metabolic conditions (e.g., type 2 diabetes, NAFLD, metabolic syndrome), but two systematic reviews included turmeric among mixed polyphenol interventions, limiting attribution.3 beneficial1 neutral4 studies