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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Turmeric and Reduced Pro-inflammatory Cytokine Levels

Research synthesisModerate evidenceModerate effect4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects of turmeric on reducing pro-inflammatory cytokine levels, with 1 neutral finding and no harmful effects. The predominant effect size was moderate to large, supported by statistically significant results in 3 of the studies. The most-studied population was adults with metabolic conditions (e.g., type 2 diabetes, metabolic syndrome), and the one study reporting duration showed effects at 365 days.

  • Effective dose range: 1500 mg/day
  • Studied populations: adults with type 2 diabetes, metabolic syndrome, NAFLD, obesity, or polycystic ovary syndrome

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Most studies lacked form data, so the effect of specific turmeric forms (e.g., curcumin vs. whole turmeric) remains unclear. The only study reporting a specific dose and duration used 1500 mg/day for 365 days; generalizability to other doses or shorter durations is limited.

Generated Jul 10, 2026
Doses used in studies
  • mg/day: 1,500 (median 1,500, IQR 1,5001,500) 1 study
Time to effect
Median: 12.2 months · IQR 12.2 months12.2 months · Range 12.2 months12.2 months — Reported in 1 of 4 studies
Safety in these studies
4 of 4 papers
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