Best Supplements for Reduced Alkaline Phosphatase Level
Ranked by research evidence. Compare 20 supplements across 24 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across all 4 studies, silymarin (milk thistle) consistently showed beneficial small-to-moderate effects on reducing alkaline phosphatase (ALP) levels, with all 4 studies reporting statistically significant findings. The most commonly studied dose was 140–420 mg daily orally, and effects were typically observed at 6–9 weeks (median study duration 63 days). Evidence predominantly comes from clinical populations, including breast cancer patients undergoing chemotherapy and adults at risk for liver injury.
Dose: 140–420 mg/day
20 supplements
- ModerateThistleAcross all 4 studies, silymarin (milk thistle) consistently showed beneficial small-to-moderate effects on reducing alkaline phosphatase (ALP) levels, with all 4 studies reporting statistically significant findings. The most commonly studied dose was 140–420 mg daily orally, and effects were typically observed at 6–9 weeks (median study duration 63 days). Evidence predominantly comes from clinical populations, including breast cancer patients undergoing chemotherapy and adults at risk for liver injury. · Dose: 140–420 mg/day4 beneficial4 studies