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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The effect of Chios mastic toothpaste on halitosis and oral hygiene in orthodontic patients: a randomized clinical trial.
- 2025-07-30
- RCT
- Journal of breath research 19(4)
- - Antigoni Alexiou
  - Ioulia-Maria Mylonopoulou
  - Spyros Papageorgiou
  - William Papaioannou
  - Iosif Sifakakis
- PubMed: 40680773
- DOI: 10.1088/1752-7163/adf1bf
5 Insights on
- High evidence
Optimistic effects of dual nano-encapsulated probiotics on breeders laying performance, intestinal barrier functions, immunity and resistance against Salmonella Typhimurium challenge.
- 2025-07-30
- RCT · n = 250
- Scientific reports 15(1)
- - Mohamed Tharwat Elabbasy
  - Asmaa T Y Kishawy
  - Walaa S Abdelaziz
  - Ahmed Abdelfattah Hassan
  - Hend S Nada
  - Reham A Elbhnsawy
  - Amany M Shosha
  - Dina Ibrahim
  - Fatma Eldemery
  - Shimaa A E Atwa
  - Wafaa R I A Sherief
  - Eman S El-Shetry
  - Ayman A Saleh
  - Doaa Ibrahim
- PubMed: 40738913
- DOI: 10.1038/s41598-025-05495-y
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis.
- 2025-07-30
- Meta-Analysis
- Systematic reviews 14(1)
- - Chongxiang Xue
  - Ying Chen
  - Cheng Tang
  - Linhua Zhao
  - Xiaolin Tong
  - Han Wang
- PubMed: 40739586
- DOI: 10.1186/s13643-025-02914-z
4 Insights on
- High evidence
Efficacy and Safety of Vitamin E in Adults With Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2025-07-29
- Review
- Cureus 17(7)
- - Helai Hussaini
  - Manpreet Kaur Dhanjal
  - Rahman Hameed Mohammed Abdul
  - Olaniyi Fadeyi
  - Najeeha A Bhatti
  - Mohammed Qasim Rauf
  - Calvin R Wei
  - Adil Amin
- PubMed: 40895855
- DOI: 10.7759/cureus.88949
4 Insights on
- Low evidence
A Review of Probiotic Supplementation and Its Impact on the Health and Well-Being of Domestic Cats.
- 2025-07-28
- Review
- Veterinary sciences 12(8)
- - Bhagavathi Sundaram Sivamaruthi
  - Periyanaina Kesika
  - Chaiyavat Chaiyasut
  - Pranom Fukngoen
  - Natarajan Sisubalan
- PubMed: 40872654
- DOI: 10.3390/vetsci12080703
2 Insights on
- Improved Gastrointestinal Health
- Reduced Inflammation
- Low evidence
Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
- 2025-07-28
- Observational · n = 3,348
- BMC medicine 23(1)
- - Shane Gordon
  - Leane Hoey
  - Helene McNulty
  - Jordan Keenan
  - Faith Pangilinan
  - Lawrence C Brody
  - Mary Ward
  - J J Strain
  - Liadhan McAnena
  - Adrian McCann
  - Anne M Molloy
  - Conal Cunningham
  - Kevin McCarroll
  - Catherine F Hughes
- PubMed: 40717068
- DOI: 10.1186/s12916-025-04276-8
1 Insight on
- Reduced Cognitive Function
- High evidence
Food Bioactive for Gut-Metabolic Axis Regulation and Microbiota Modulation.
- 2025-07-26
- Foods (Basel, Switzerland) 14(15)
- - Xiaoyan Liu
  - Tianjiao Wang
  - Ziwei Liu
  - Guangsen Fan
- PubMed: 40807554
- DOI: 10.3390/foods14152617
4 Insights on
- Low evidence
Evaluation of Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, Lactobacillus sporogenes, Saccharomyces Boulardi multistrain probiotic formulation in acute gastroenteritis: a real-world observational study (MAESTRO).
- 2025-07-25
- Observational · n = 683
- BMC nutrition 11(1)
- - Bhavna Darshan Patel
  - Girish Kulkarni
  - Swagata Chowdhuri
  - Animesh Arya
  - Kaithayil Mammen John
  - Ashwini Suyog Patki Doshi
  - Rathish Nair
  - Krishnaprasad Korukonda
- PubMed: 40713758
- DOI: 10.1186/s40795-025-01127-w
5 Insights on
- High evidence
Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis.
- 2025-07-25
- Meta-Analysis · n = 151
- International journal of molecular sciences 26(15)
- - Isabel Viña
  - Juan R Viña
- PubMed: 40806357
- DOI: 10.3390/ijms26157224
8 Insights on
- High evidence
- Rigorous Journal
Effects of spore-forming probiotic Bacillus subtilis HU58™ in children with antibiotic-associated diarrhoea: a randomised, double-blind, placebo-controlled trial.
- 2025-07-25
- RCT · n = 68
- Beneficial microbes 17(1)
- - K Sorensen
  - P Jog
  - S Mankar
  - C Holz
  - S Jadhav
- PubMed: 40716758
- DOI: 10.1163/18762891-bja00086
3 Insights on
- High evidence
- Rigorous Journal
Probiotics as a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis.
- 2025-07-25
- Review · n = 657
- Current research in food science 11
- - Jing Lu
  - Xiaoxiao Dong
  - Ziqi Gao
  - Huizhen Yan
  - Dilireba Shataer
  - Liang Wang
  - Yanan Qin
  - Minwei Zhang
  - Jiayi Wang
  - Jie Cui
  - Shengyang Zhou
- PubMed: 40697756
- DOI: 10.1016/j.crfs.2025.101138
4 Insights on
- High evidence
Footprint of Domestic Processing on Safety and Functional Properties of Italian Black Garlic.
- 2025-07-24
- Foods (Basel, Switzerland) 14(15)
- - Davide Addazii
  - Chiara Cevoli
  - Flavia Casciano
  - Federico Ferioli
  - Tullia Gallina Toschi
  - Andrea Gianotti
  - Lorenzo Nissen
- PubMed: 40807532
- DOI: 10.3390/foods14152595
1 Insight on
- Enhanced Prebiotic Activity
- Low evidence
Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.
- 2025-07-24
- Meta-Analysis · n = 337
- Clinical and experimental medicine 25(1)
- - Yinyan Shao
  - Junwei Shi
- PubMed: 40705097
- DOI: 10.1007/s10238-025-01809-6
3 Insights on
- High evidence
Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial.
- 2025-07-24
- RCT · n = 262
- Journal of intensive care medicine 41(2)
- - Jhuma Sankar
  - Aravindhan Manoharan
  - Rakesh Lodha
  - H P Sharma
  - S K Kabra
- PubMed: 40708328
- DOI: 10.1177/08850666251362121
3 Insights on
- High evidence
- Large Human Trial
Potential relationship between gut microbiota and animal diarrhea: a systematic review.
- 2025-07-24
- Review
- Frontiers in microbiology 16
- - Yuxin Zhang
  - Yonggui Ma
  - Youchao Qi
- PubMed: 40778205
- DOI: 10.3389/fmicb.2025.1637331
2 Insights on
- Reduced Diarrhea Incidence
- Reduced Diarrhea
- Low evidence
Effects of soy isoflavones on menopausal symptoms in perimenopausal women: a systematic review and meta-analysis.
- 2025-07-23
- Meta-Analysis · n = 748
- PeerJ 13
- - Haodi Luan
  - Qianqian Liu
  - Yahui Guo
  - Hua Fan
  - Sileng A
  - Jing Lin
- PubMed: 40718787
- DOI: 10.7717/peerj.19715
15 Insights on
- High evidence
- Rigorous Journal
Partially hydrolyzed, whey-based infant formula with six human milk oligosaccharides, B. infantis LMG11588, and B. lactis CNCM I-3446 is safe, well tolerated, and improves gut health: a staged analysis of a randomized trial.
- 2025-07-23
- RCT · n = 313
- Frontiers in nutrition 12
- - Jean-Charles Picaud
  - Olivier Claris
  - Mercedes Gil-Campos
  - Ignacio Salamanca De La Cueva
  - Luc Cornette
  - Philippe Alliet
  - André Léké
  - Mireille Castanet
  - Hugues Piloquet
  - Virginie de Halleux
  - Delphine Mitanchez
  - Yvan Vandenplas
  - Pierre Maton
  - Frank Jochum
  - Dirk Olbertz
  - Sergio Negre Policarpo
  - Luca Lavalle
  - Cecilia Fumero
  - Paula Rodriguez-Garcia
  - Janne Marie Moll
  - Irma Silva-Zolezzi
  - Boutaina Zemrani
  - Nicholas P Hays
  - Norbert Sprenger
  - Javier Miranda-Mallea
- PubMed: 40771223
- DOI: 10.3389/fnut.2025.1628847
2 Insights on
- Reduced Faecal pH
- Healthy Age-Appropriate Growth
- High evidence
Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.
- 2025-07-23
- Systematic Review · n = 928
- Frontiers in pharmacology 16
- - Weidong Wu
  - Tianwei Meng
  - Fangfang Jin
  - Junwei Li
  - Jiahao Huang
  - Zhuang Guo
  - Miao Yu
  - Yanyan Zhou
- PubMed: 40771919
- DOI: 10.3389/fphar.2025.1588284
17 Insights on
- High evidence
Efficacy of probiotics pretreatment in Helicobacter pylori eradication therapy: a systematic review and meta-analysis of clinical outcomes.
- 2025-07-23
- Meta-Analysis · n = 144
- Annals of medicine 57(1)
- - Yinghui Zhang
  - Mengtian Tu
  - Ping Long
  - Jing Zheng
  - Guanghong Du
  - Shiyu Xiao
  - Caiping Gao
- PubMed: 40697099
- DOI: 10.1080/07853890.2025.2533431
3 Insights on
- High evidence
Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.
- 2025-07-23
- Meta-Analysis · n = 894
- Frontiers in immunology 16
- - Dongsheng Wu
  - Yuang Dong
  - Dongyang Zhang
  - Tongtong Wang
  - Haipeng Ye
  - Wei Zhang
- PubMed: 40771814
- DOI: 10.3389/fimmu.2025.1617694
5 Insights on
- High evidence
Impact of Heyndrickxia (Bacillus) coagulans GBI-30, 6086 (BC30) probiotic on gastrointestinal function in healthy adults: a randomised controlled trial.
- 2025-07-22
- RCT · n = 111
- Beneficial microbes 17(1)
- - H Gang
  - J Wei
  - L V McFarland
  - R Zahra
  - M E Saez
  - R Blanco-Rojo
  - M Millette
- PubMed: 40707016
- DOI: 10.1163/18762891-bja00084
1 Insight on
- Improved Gastrointestinal Function
- High evidence
- Large Human Trial
- Rigorous Journal
The Effectiveness of Hesperidin, Diosmin and Proanthocyanidins Nutritional Supplementation on Cognitive and Motor Functions in Older Adults: A Pilot Randomized Control Study.
- 2025-07-22
- RCT
- Journal of the American Nutrition Association 45(1)
- - Silvia Giovannini
  - Alessandra Lauria
  - Anna Maria Malizia
  - Elisabetta Lama
  - Nadia Morciano
  - Lorenzo Biscotti
  - Claudia Loreti
  - Letizia Castelli
- PubMed: 40694049
- DOI: 10.1080/27697061.2025.2526600
4 Insights on
- High evidence
The effects of collagen peptide supplementation on appetite and post-exercise energy intake in females: a randomised controlled trial.
- 2025-07-21
- RCT
- The British journal of nutrition 134(4)
- - Kirsty M Reynolds
  - Emily J Hansell
  - Josh Thorley
  - Mark P Funnell
  - Alice E Thackray
  - David J Stensel
  - Stephen J Bailey
  - Lewis J James
  - Janne Prawitt
  - Nicolina Virgilio
  - Tom Clifford
- PubMed: 40685650
- DOI: 10.1017/s0007114525103851
10 Insights on
- High evidence
Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials.
- 2025-07-21
- Systematic Review
- Frontiers in medicine 12
- - Qifeng Yang
  - Haoying Li
  - Hanxin Zhang
  - Luyao Ma
  - Xiaofeng Zhang
  - Jingping Wu
- PubMed: 40761858
- DOI: 10.3389/fmed.2025.1582946
1 Insight on
- Improved Skin Elasticity
- High evidence
Effects of Vitamin D3 Supplementation on Inflammatory Markers in Overweight and Obese Children and Adolescents: A Systematic Review.
- 2025-07-20
- Review · n = 294
- Life (Basel, Switzerland) 15(7)
- - Maria Krajewska
  - Ewelina Witkowska-Sędek
- PubMed: 40724644
- DOI: 10.3390/life15071142
5 Insights on
- High evidence
Efficacy of Superoxide Dismutase in the Treatment of Vitiligo: A Systematic Review.
- 2025-07-19
- Review
- Cureus 17(7)
- - Virginia Salazar-Formoso
  - Martha Alejandra Morales-Sánchez
- PubMed: 40842761
- DOI: 10.7759/cureus.88335
2 Insights on
- Improved Repigmentation
- Reduced Vitiligo Extent Score
- Low evidence
Persistent symptoms in euthyroid Hashimoto's thyroiditis: current hypotheses and emerging management strategies.
- 2025-07-18
- Review
- Frontiers in endocrinology 16
- - Hui Zhang
  - Wenting Tong
  - Weiyong Zeng
  - Hongyan Luo
  - Licai Zhang
  - Jiasheng Feng
  - Yang Xiao
  - Gankun Wang
- PubMed: 40756512
- DOI: 10.3389/fendo.2025.1627787
1 Insight on
- Improved Health-related Quality of Life
- Low evidence
Anti-inflammatory effects of Bifidobacterium infantis M-63 during the early postnatal period in term infants.
- 2025-07-18
- RCT
- Pediatric research 99(5)
- - Chendong Xu
  - Toshitaka Odamaki
  - Akari Hiraku
  - Setsuko Nakata
  - Satoshi Arai
  - Noriyuki Iwabuchi
  - Miyuki Tanaka
  - Takahisa Tsuno
  - Masahiko Nakamura
- PubMed: 40681696
- DOI: 10.1038/s41390-025-04263-y
5 Insights on
- High evidence
Effects of vitamin E administration on serum lipid profile in diabetic patients: a grade-assessed systematic review and dose-response meta-analysis of RCTs.
- 2025-07-18
- Review
- Diabetology & metabolic syndrome 17(1)
- - Mehdi Karimi
  - Mohammad Amin Karimi
  - Farzad Fayedeh
  - Fatemeh Ziyafati Kafi
  - Kimia Kazemi
  - Sharareh Jahangiri
  - Omid Asbaghi
- PubMed: 40682150
- DOI: 10.1186/s13098-025-01833-2
4 Insights on
- Low evidence
Protocol for a randomized trial comparing a synbiotic-enriched goat milk-based infant formula with a commercially available cow milk-based formula: effects on gastrointestinal symptoms, quality of life, and growth in infants with cow milk-related symptoms.
- 2025-07-17
- RCT
- Nutrition journal 24(1)
- - Mateusz Jankiewicz
  - Hania Szajewska
- PubMed: 40676640
- DOI: 10.1186/s12937-025-01183-9
3 Insights on
- High evidence