Best Supplements for Reduced Diarrhea
Ranked by research evidence. Compare 28 supplements across 39 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence8 studies
Across 8 studies, all reported beneficial effects of Saccharomyces boulardii on reducing diarrhea, with effect sizes ranging from small to large. The evidence shows moderate-to-large effects in clinical populations, particularly for preventing antibiotic-associated diarrhea and reducing diarrhea during Helicobacter pylori eradication therapy, with doses commonly around 250–500 mg/day. Most studies involved patients with specific clinical conditions (e.g., pelvic radiotherapy, Helicobacter pylori infection, critically ill tube-fed patients), rather than healthy adults.
Dose: 250–500 mg/day (or up to 500 mg four times a day) - Low evidence3 studies
Across 3 randomized controlled trials, 1 reported a beneficial small-sized effect of Saccharomyces boulardii on reduced diarrhea, while 2 found neutral effects. The most-studied dose was 500 mg twice daily, and study populations were clinical (patients with SIBO, IBS-D, or undergoing H. pylori eradication). Median study duration was 15 days.
Dose: 500 mg twice daily
- Highsaccharomyces boulardiiAcross 8 studies, all reported beneficial effects of Saccharomyces boulardii on reducing diarrhea, with effect sizes ranging from small to large. The evidence shows moderate-to-large effects in clinical populations, particularly for preventing antibiotic-associated diarrhea and reducing diarrhea during Helicobacter pylori eradication therapy, with doses commonly around 250–500 mg/day. Most studies involved patients with specific clinical conditions (e.g., pelvic radiotherapy, Helicobacter pylori infection, critically ill tube-fed patients), rather than healthy adults. · Dose: 250–500 mg/day (or up to 500 mg four times a day)8 beneficial8 studies
- LowSaccharomyces boulardiiAcross 3 randomized controlled trials, 1 reported a beneficial small-sized effect of Saccharomyces boulardii on reduced diarrhea, while 2 found neutral effects. The most-studied dose was 500 mg twice daily, and study populations were clinical (patients with SIBO, IBS-D, or undergoing H. pylori eradication). Median study duration was 15 days. · Dose: 500 mg twice daily1 beneficial2 neutral3 studies