Best Supplements for Reduced Diarrhea
Ranked by research evidence. Compare 28 supplements across 42 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence9 studies
Across 9 studies, all reported beneficial effects of Saccharomyces boulardii on reducing diarrhea, with effect sizes ranging from small to large. The predominant effect size is moderate, and the evidence is strongest in clinical populations, particularly those undergoing Helicobacter pylori eradication therapy, pelvic radiotherapy, or antibiotic treatment. The median study duration was 14 days, and the most commonly reported dose was 500 mg four times a day, though doses varied.
Dose: 500 mg four times a day - Low evidence3 studies
Across 3 randomized controlled trials, 1 reported a small beneficial effect of Saccharomyces boulardii on reducing diarrhea, while 2 found neutral small effects; the beneficial finding was statistically significant in a clinical population with SIBO. The median study duration was 15 days, and the most common dose was 500 mg twice daily.
Dose: 500 mg twice daily - Low evidence3 studies
Across 3 studies on Lactobacillus reuteri DSM 17938 for reduced diarrhea, only 1 reported a statistically significant beneficial effect (moderate effect size), while 2 found neutral results with small effect sizes. The single beneficial study used a dose of 4 × 10^8 colony-forming units/day in hospitalized children aged 6–36 months with acute diarrhea. The evidence base is small, and the predominant effect across all studies is neutral with a small magnitude.
Dose: 4 × 10^8 colony-forming units/dayProduct matchBioGaia — Kids, Immune Active with L. Reuteri + Vitamin D, Orange· $26.99 · ★4.8 (510)
- Highsaccharomyces boulardiiAcross 9 studies, all reported beneficial effects of Saccharomyces boulardii on reducing diarrhea, with effect sizes ranging from small to large. The predominant effect size is moderate, and the evidence is strongest in clinical populations, particularly those undergoing Helicobacter pylori eradication therapy, pelvic radiotherapy, or antibiotic treatment. The median study duration was 14 days, and the most commonly reported dose was 500 mg four times a day, though doses varied. · Dose: 500 mg four times a day9 beneficial9 studies
- LowSaccharomyces boulardiiAcross 3 randomized controlled trials, 1 reported a small beneficial effect of Saccharomyces boulardii on reducing diarrhea, while 2 found neutral small effects; the beneficial finding was statistically significant in a clinical population with SIBO. The median study duration was 15 days, and the most common dose was 500 mg twice daily. · Dose: 500 mg twice daily1 beneficial2 neutral3 studies
- LowLactobacillus reuteri DSM 17938Across 3 studies on Lactobacillus reuteri DSM 17938 for reduced diarrhea, only 1 reported a statistically significant beneficial effect (moderate effect size), while 2 found neutral results with small effect sizes. The single beneficial study used a dose of 4 × 10^8 colony-forming units/day in hospitalized children aged 6–36 months with acute diarrhea. The evidence base is small, and the predominant effect across all studies is neutral with a small magnitude. · Dose: 4 × 10^8 colony-forming units/day1 beneficial2 neutral3 studies