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Evidence-Based Supplement Research
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Lactobacillus

Safety profile

5 studies reporting safety data1 serious adverse event

Across 5 clinical studies, no specific adverse events were found to be significantly increased compared to control. One study reported a case of serious adverse events (Lactobacillus sepsis and D-lactic acidosis) in vulnerable patients, but this was described qualitatively without quantified group comparison. In 4 studies, Lactobacillus was generally well tolerated or showed comparable safety profiles to controls, with no significant differences in gastrointestinal or other safety markers.

Caveats: The evidence base is small, and most studies were not designed to detect rare adverse events. Findings regarding serious events come from specific patient populations (e.g., those with central venous catheters or malabsorption), and may not generalize to healthy individuals.

Most-studied combinations with Lactobacillus

most supplement research is combination research
Also studied with:Bifidobacterium (9)

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