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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Lactobacillus

Safety profile

5 studies reporting safety data1 serious adverse event

Across 5 clinical studies reporting safety data on Lactobacillus probiotics, no specific adverse events were found to be significantly increased compared to control. One study reported a case of serious adverse events (Lactobacillus sepsis and D-lactic acidosis) in vulnerable patients with central venous catheters or malabsorption, but these were unquantified in terms of incidence. The remaining four studies described the probiotic as generally well tolerated or reported no significant differences in safety outcomes, with one specifically finding no difference in diarrhea incidence.

Caveats: The reported serious adverse events occurred in patients with specific risk factors, limiting generalizability to healthy populations; overall evidence base is small (5 studies), and most reports are based on general tolerability statements rather than systematic safety monitoring, so rare adverse events may not be captured.

Most-studied combinations with Lactobacillus

most supplement research is combination research
Also studied with:Bifidobacterium (9)
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