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Evidence-Based Supplement Research
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Lactobacillus

Safety profile

4 studies reporting safety data1 serious adverse event

Across 4 clinical studies, no adverse events were found to be increased with Lactobacillus compared to control. One study reported no significant difference in diarrhea incidence between groups, while three studies described the probiotic as generally well tolerated or noted safety improvements in disease management. One serious adverse event finding (Lactobacillus sepsis and D-lactic acidosis) was reported in a specific high-risk patient population. Overall, Lactobacillus was associated with a favorable tolerability profile in the assessed studies, though the evidence base is limited.

Caveats: Evidence is limited to a small number of studies (N=4), and serious adverse events (e.g., sepsis) have been reported in vulnerable patients such as those with central venous catheters or malabsorption. Studies were often not primarily powered for safety endpoints, and the specific strains or formulations may differ across trials, limiting generalizability.

Most-studied combinations with Lactobacillus

most supplement research is combination research
Also studied with:Bifidobacterium (9)

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