Best Supplements for Reduced Inflammation
Ranked by research evidence. Compare 130 supplements across 233 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence6 studies
Across all 6 studies, vitamin D supplementation consistently showed beneficial effects on reducing inflammation, with 5 of 6 reporting statistically significant findings. The predominant effect size was small, though the highest-quality meta-analysis reported a moderate effect (SMD: -0.40, 95% CI: -0.48 to -0.32, p < 0.01) in older adults. No consistent dose range or supplement form was identified across studies, and effects were observed in older adults and clinical populations with inflammatory conditions (e.g., rheumatoid arthritis, spinal cord injury).
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208) - Moderate evidence9 studies
Across 9 studies, all reported beneficial effects for reduced inflammation, with predominantly small effect sizes. Evidence includes a meta-analysis and a systematic review, but only one study reached statistical significance. Most studies assessed general probiotic interventions rather than specifically Lactobacillus acidophilus L-92, limiting direct applicability.
- Moderate evidence8 studies
Across 8 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing inflammation, with 5 showing moderate-sized effects and 3 showing small effects. Statistically significant findings were reported in 3 studies, including a meta-analysis and a randomized controlled trial. Evidence spans diverse clinical populations such as women with gestational diabetes, patients with multiple sclerosis, and individuals with obesity or inflammatory bowel disease, but no consistent dose or form was reported.
130 supplements
- LowLactobacillus rhamnosusAcross 13 studies, 13 reported beneficial effects of Lactobacillus rhamnosus on reducing inflammation, with effect sizes predominantly moderate (11 moderate, 1 small, 1 large). The evidence is strongest in pediatric asthma and chronic kidney disease populations, though study durations and doses were not consistently reported. Only 2 studies reached statistical significance, and most findings are from in vitro or animal models.15 beneficial15 studies
- ModerateLactobacillus acidophilus L-92Across 9 studies, all reported beneficial effects for reduced inflammation, with predominantly small effect sizes. Evidence includes a meta-analysis and a systematic review, but only one study reached statistical significance. Most studies assessed general probiotic interventions rather than specifically Lactobacillus acidophilus L-92, limiting direct applicability.9 beneficial9 studies
- LowBifidobacterium plantarumAcross 8 studies, 7 reported beneficial effects on reducing inflammation, with a predominant moderate effect size. The most robust evidence comes from a meta-analysis of athletes showing a statistically significant reduction in TNF-α (ES = -0.59). Evidence is largely from reviews and animal studies, limiting the strength of conclusions for specific human populations.8 beneficial1 neutral9 studies
- ModerateLactobacillus salivarius UCC118Across 8 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing inflammation, with 5 showing moderate-sized effects and 3 showing small effects. Statistically significant findings were reported in 3 studies, including a meta-analysis and a randomized controlled trial. Evidence spans diverse clinical populations such as women with gestational diabetes, patients with multiple sclerosis, and individuals with obesity or inflammatory bowel disease, but no consistent dose or form was reported.8 beneficial8 studies
- Very lowLactobacillus brevis SBC8803Across 5 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on reduced inflammation, with a predominant effect size of moderate. The evidence includes one randomized controlled trial showing a moderate, statistically significant benefit on exercise-induced inflammation in healthy adults. Most studies are reviews or preclinical, and no consistent dose range or form was reported.8 beneficial8 studies
- LowSaccharomyces cerevisiaeAcross 6 studies, all reported beneficial effects on inflammation, with effect sizes ranging from small to large but predominantly moderate. The only human RCT (n=12) showed moderate beneficial effects on microvascular inflammatory responses. Most evidence comes from in vitro and animal studies, and no consistent dose or form was reported.7 beneficial7 studies
- HighVitamin DAcross all 6 studies, vitamin D supplementation consistently showed beneficial effects on reducing inflammation, with 5 of 6 reporting statistically significant findings. The predominant effect size was small, though the highest-quality meta-analysis reported a moderate effect (SMD: -0.40, 95% CI: -0.48 to -0.32, p < 0.01) in older adults. No consistent dose range or supplement form was identified across studies, and effects were observed in older adults and clinical populations with inflammatory conditions (e.g., rheumatoid arthritis, spinal cord injury).6 beneficial6 studies
- LowLactobacillus amylovorusAcross 4 studies, all reported beneficial effects on inflammation, with effect sizes ranging from small to moderate. One meta-analysis of 25 RCTs showed a small but statistically significant reduction in C-reactive protein (-0.99 mg/L). However, the remaining studies were conducted in vitro or in animal models and did not report statistical significance. No specific dose or form data were available.4 beneficial4 studies
- LowLactobacillus rhamnosus GR-1Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus rhamnosus GR-1 on reducing inflammation, with 2 of 3 findings statistically significant. Evidence is derived from in vitro, animal, and cell-based models, with no human clinical trials available. No consistent dose range or study duration was reported across studies.4 beneficial4 studies
- LowBifidobacterium breve Bb-18Across 4 studies, all reported beneficial effects on inflammation, with effect sizes mixed (small to moderate). The highest-quality evidence (a meta-analysis of microbiome-targeted therapies) showed a small beneficial effect on inflammatory markers in type 2 diabetes. However, all studies used multi-strain products or other interventions, not Bifidobacterium breve Bb-18 alone, making direct evidence for this specific strain lacking.4 beneficial4 studies
- Very lowBifidobacterium animalis subsp. lactis BB-12Across 4 studies, all reported beneficial effects on inflammation, with effect sizes predominantly small (3 small, 1 moderate). However, all evidence comes from reviews and one animal model study; no human clinical trials were identified. No dose range or specific population could be determined due to inconsistent reporting.4 beneficial4 studies
- ModerateVitamin EAcross 3 studies, all reported beneficial effects of vitamin E on reducing inflammation, with effect sizes ranging from small to large (mixed). The median study duration was 84 days (12 weeks), though only one study reported duration. The most studied dose was 335 mg/day in a single RCT, and populations included clinical groups such as gastrointestinal surgery patients, older women with sarcopenia, and adults with NAFLD/NASH. The evidence shows moderate consistency for a beneficial effect, but the magnitude varies considerably.3 beneficial3 studies
- LowBifidobacterium lactis Bb-02Across 3 studies, all 3 reported beneficial effects on inflammation markers, with predominantly small effect sizes. Evidence comes from populations including type 2 diabetes, gestational diabetes mellitus, and neurodegenerative diseases. Study doses and durations were not consistently reported.3 beneficial3 studies
- LowLactobacillus acidophilus La-14Across 3 studies, all reported beneficial effects on inflammation, with effect sizes ranging from small to moderate. The evidence is strongest for populations with gestational diabetes mellitus (GDM), where moderate effects on inflammatory markers (e.g., CRP, IL-6) were observed. No consistent dose or study duration was reported across the studies.3 beneficial3 studies
- LowLactobacillus casei PXN 37Across 3 studies, all reported beneficial effects, with two meta-analyses (total n=703) finding statistically significant reductions in inflammatory markers such as IL-6, TNFα, and hs-CRP. The predominant effect size is moderate, and the evidence primarily comes from patients with autoimmune and neurodegenerative diseases, though one study showed effects only in depressed patients with somatic comorbidities. No consistent dose or duration was reported across studies.3 beneficial3 studies
- LowPomegranateAcross all 3 studies, pomegranate showed beneficial effects on reducing inflammation, with a predominant moderate effect size. Two of the three studies reported statistically significant findings. The evidence is drawn from systematic reviews covering diverse populations such as arthritis patients and athletes, but no consistent dose or form was reported.3 beneficial3 studies
- Very lowLactobacillus casei rhamnosusAcross 3 studies, all reported beneficial effects of Lactobacillus casei rhamnosus on reducing inflammation, with effect sizes ranging from small to moderate. The evidence is drawn from review articles and animal research, with no statistically significant findings reported. The most studied population was women with gestational diabetes mellitus, but the evidence base is too small to draw firm conclusions.3 beneficial3 studies
- LowResveratrolAcross 3 studies, 2 reported beneficial effects (small to moderate) on reducing inflammation, while the highest-quality RCT found no significant benefit. The predominant effect size is mixed (small to moderate), and the evidence base is limited to overweight and obese adults, with only one study providing dose and duration data (150 mg/day for 28 days). Overall, the findings are preliminary and inconsistent.2 beneficial1 neutral3 studies