Lactobacillus salivarius UCC118 and Reduced Inflammation

Research synthesisModerate evidenceModerate effect8 studies · 8 beneficial · 0 neutral · 0 harmful

All 8 studies reported beneficial effects of Lactobacillus salivarius UCC118 on reducing inflammation, with a predominant moderate effect size. Three studies were statistically significant. The strongest evidence comes from a meta-analysis in women with gestational diabetes mellitus (small effect) and an RCT in patients with multiple sclerosis (moderate effect). Doses were not consistently reported across studies.

Studied populations: women with gestational diabetes mellitus, patients with relapsing-remitting multiple sclerosis

Caveats: Many studies are reviews that do not isolate the specific strain L. salivarius UCC118; results may reflect broader probiotic effects. Doses were not reported, limiting dose-response conclusions. The meta-analysis reported a small effect size, indicating modest clinical impact. Further research with standardized strains and doses is needed.

Generated May 10, 2026

8 of 8 papers

The role of probiotics and synbiotics on treatment of gestational diabetes: systematic review and meta-analysis.
- 2024-02
- Review · n = 896
- AJOG global reports 4(1)
- - Arresta Vitasatria Suastika
  - I Gde Raka Widiana
  - Ni Nengah Dwi Fatmawati
  - Ketut Suastika
  - Ivana Beatrice Paulus
  - I Nengah Sujaya
- PubMed: 38322777
- DOI: 10.1016/j.xagr.2023.100285
9 Insights on
- Reduced Inflammation
- High evidence
significant reduction of the mean difference was observed in ... C-reactive protein (mean difference, -1.93 dL; 95% confidence interval, -2.3 to -1.56)
Effect
Beneficial
Effect size
Small
Significant
Yes
Probiotic supplementation and systemic inflammation in relapsing-remitting multiple sclerosis: A randomized, double-blind, placebo-controlled trial.
- 2022-09-20
- RCT
- Frontiers in neuroscience 16
- - Mehran Rahimlou
  - Shima Nematollahi
  - Durdana Husain
  - Nasrin Banaei-Jahromi
  - Nastaran Majdinasab
  - Seyed Ahmad Hosseini
- PubMed: 36203797
- DOI: 10.3389/fnins.2022.901846
1 Insight on
- Reduced Inflammation
- High evidence
probiotic supplementation compared to the placebo caused a significant reduction in the serum levels of CRP... TNF-α... and IFN-γ... Also, we found a significant increase in the FOXP3 and TGF-β levels in the intervention group
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity.
- 2024-04-30
- Review
- Nutrients 16(9)
- - A K M Humayun Kober
  - Sudeb Saha
  - Mutamed Ayyash
  - Fu Namai
  - Keita Nishiyama
  - Kazutoyo Yoda
  - Julio Villena
  - Haruki Kitazawa
- PubMed: 38732619
- DOI: 10.3390/nu16091373
10 Insights on
- Reduced Inflammation
- Moderate evidence
- Rigorous Journal
Furthermore, probiotics effectively increase insulin sensitivity and decrease systemic inflammation.
Effect
Beneficial
Effect size
Moderate
The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease.
- 2020-11-01
- Review
- Microorganisms 8(11)
- - Spase Stojanov
  - Aleš Berlec
  - Borut Štrukelj
- PubMed: 33139627
- DOI: 10.3390/microorganisms8111715
5 Insights on
- Reduced Inflammation
- Moderate evidence
- Highly Cited
The most commonly tested probiotics for modifying the F/B ratio and treating obesity and IBD are from the genus Lactobacillus.
Effect
Beneficial
Effect size
Small
Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review.
- 2025-03-08
- Review
- Redox report : communications in free radical research 30(1)
- - Sia Shin
  - Siqi Chen
  - Kangzhe Xie
  - Suehad Abou Duhun
  - Tamara Ortiz-Cerda
- PubMed: 40056427
- DOI: 10.1080/13510002.2025.2471737
3 Insights on
- Reduced Inflammation
- Low evidence
studies showed significant anti-inflammatory, gut microbiota restoring, antioxidant effects of polyphenols, polysaccharides, emodin, short-chain fatty acids (SCFA; including butyrate, propionate and acetate), and probiotics although some contrasting results were noted.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
An Update on the Effects of Probiotics on Gastrointestinal Cancers.
- 2021-12-21
- Review
- Frontiers in pharmacology 12
- - Amirhossein Davoodvandi
  - Farzaneh Fallahi
  - Omid Reza Tamtaji
  - Vida Tajiknia
  - Zarrin Banikazemi
  - Hadis Fathizadeh
  - Mohammad Abbasi-Kolli
  - Michael Aschner
  - Maryam Ghandali
  - Amirhossein Sahebkar
  - Mohsen Taghizadeh
  - Hamed Mirzaei
- PubMed: 34992527
- DOI: 10.3389/fphar.2021.680400
1 Insight on
- Reduced Inflammation
- Low evidence
clinical investigations suggest that probiotic administration in cancer patients decreases the incidence of postoperative inflammation
Effect
Beneficial
Effect size
Small
The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy.
- 2017-06-02
- Review
- Oncotarget 8(35)
- - Ya-Hui Ding
  - Lin-Yan Qian
  - Jie Pang
  - Jing-Yang Lin
  - Qiang Xu
  - Li-Hong Wang
  - Dong-Sheng Huang
  - Hai Zou
- PubMed: 28938693
- DOI: 10.18632/oncotarget.18346
2 Insights on
- Reduced Inflammation
- Low evidence
Some <i>Lactobacillus</i> stains can upregulate the activity of regulatory T-lymphocytes, suppress T-lymphocyte helper (Th) cells Th1, Th17, alter the Th1/Th2 ratio, influence the subsets ratio of M1/M2 macrophages, inhibit foam cell formation by suppressing macrophage phagocytosis of oxidized low-density lipoprotein, block the activation of the immune system with dendritic cells, which are expected to suppress the atherosclerosis-related inflammation.
Effect
Beneficial
Effect size
Moderate
Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice.
- 2025-02-04
- Microbiology spectrum 13(2)
- - Wenhong Yang
  - Tao Li
  - Shixiang An
  - Rong Chen
  - Yuxin Zhao
  - Jiaxian Cui
  - Mingyu Zhang
  - Jingkun Lu
  - Yunpeng Tian
  - Lili Bao
  - Pengwei Zhao
- PubMed: 39792005
- DOI: 10.1128/spectrum.01861-24
4 Insights on
- Reduced Inflammation
- Low evidence
The tumor necrosis factor-α and interleukin-6 were reduced by LZZAY01.
Effect
Beneficial
Effect size
Moderate