Research synthesisModerate evidenceModerate effect8 studies · 8 beneficial · 0 neutral · 0 harmful
Across 8 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing inflammation, with 5 showing moderate-sized effects and 3 showing small effects. Statistically significant findings were reported in 3 studies, including a meta-analysis and a randomized controlled trial. Evidence spans diverse clinical populations such as women with gestational diabetes, patients with multiple sclerosis, and individuals with obesity or inflammatory bowel disease, but no consistent dose or form was reported.
- Studied populations: women with gestational diabetes mellitus, patients with relapsing-remitting multiple sclerosis, individuals with obesity or inflammatory bowel disease, cancer patients (postoperative), and atherosclerosis-related models
Caveats: Available evidence is overwhelmingly positive (8 of 8 studies beneficial) — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Additionally, only 3 of 8 studies reported statistically significant findings — the true effect may be smaller than the predominant direction suggests. Most studies are reviews or animal/in vitro work; only one meta-analysis and one RCT with adequate sample size are present. Doses and forms were not consistently reported, limiting dose-response conclusions.
Generated Jul 11, 2026