Research synthesisModerate evidenceModerate effect8 studies · 8 beneficial · 0 neutral · 0 harmful
Across 8 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing inflammation, with effect sizes ranging from small to moderate. Moderate evidence from a large meta-analysis (n=896) in women with gestational diabetes showed a significant reduction in C-reactive protein. The most commonly studied populations were individuals with metabolic or inflammatory conditions, though dose ranges and study durations were not consistently reported.
- Studied populations: women with gestational diabetes mellitus, patients with relapsing-remitting multiple sclerosis, individuals with obesity and inflammatory bowel disease, cancer patients
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Only 3 of 8 studies reported statistically significant findings, suggesting the effect may be less robust than the direction implies. Many studies were reviews without original data, and dose, form, and duration were not systematically reported, limiting practical guidance.
Generated Jun 11, 2026