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Saccharomyces cerevisiae

What does the research say about Saccharomyces cerevisiae?

6 health outcomes synthesised

Research on Saccharomyces cerevisiae, a probiotic yeast, has been synthesized across 6 health outcomes, covering inflammation, immune function, intestinal barrier function, blood pressure, growth performance, and antioxidant status. The strongest evidence — based on the largest number of studies — is for reduced inflammation, where all 6 studies reported beneficial effects, though the evidence strength is rated low due to a small study base and limited human data. No consistent effective dose emerged across outcomes, and most studies were conducted in animals or in vitro, with human data sparse.

Strongest evidence: No outcomes reached high or moderate evidence strength. Reduced inflammation is supported by 6 studies (all beneficial, moderate effect size), but evidence strength is low; only 1 small human RCT (n=12) is included, showing reduced microvascular inflammation. Improved immune function (5 studies, all beneficial) also rates low in evidence strength, with no studies reaching statistical significance.

Mixed or weaker evidence: All remaining outcomes — intestinal barrier function (3 studies, low evidence), blood pressure (3 studies, low), growth performance (3 reviews, low), and total antioxidant status (3 studies, very low evidence) — are supported by small numbers of studies, all in animals or in vitro. None have human trial data, and statistical significance was uncommon. Effect sizes are consistently moderate, but caveats about publication bias and small evidence bases limit confidence.

Effective dose patterns: No specific effective dose ranges were reported across any outcome. Most studies did not report dose or form consistently, so no cross-cutting dose patterns can be identified.

Population insights: Human data are extremely limited. The only human study (n=12) involved inflammation outcomes. Animal populations included poultry, swine, livestock, and rodents; immune function studies included elderly and high-risk groups but were not statistically significant. No specific population consistently benefited more than others.

Notable caveats: Publication bias is a concern across most outcomes — null results are less likely to be published. The entire evidence base is small (3–6 studies per outcome) and preliminary. Most studies are non-human; applicability to human supplementation is uncertain. No study provided sufficient dosing guidance for practical use.

Frequently asked

  • What is Saccharomyces cerevisiae good for according to research?
    The most researched benefit is reduced inflammation, with all 6 studies reporting beneficial effects, including a small human RCT (n=12). Improved immune function was reported in all 5 studies, though none reached statistical significance. Intestinal barrier function, blood pressure, growth performance, and antioxidant status each have 3 studies showing benefit, but all are from animal or in vitro research, with no human trials.
  • What dose of Saccharomyces cerevisiae is typically used in studies?
    Doses were not consistently reported across the syntheses. For none of the 6 outcomes was a specific effective dose range identified. Most studies lacked dosing information, making it impossible to derive a typical or effective dose from the current evidence base.
  • Who benefits most from Saccharomyces cerevisiae?
    Human data are too limited to identify specific subgroups. The only human study (n=12) was on inflammation. Animal studies across several outcomes suggest potential benefits in poultry, swine, and livestock. Immune function studies included elderly and high-risk groups but did not report statistically significant results, so no population can be identified as benefiting most.
  • Are there caveats or limitations in the research on Saccharomyces cerevisiae?
    Yes. The evidence base is small (3–6 studies per outcome) and rated low or very low in strength. Publication bias is likely — null results are underreported. Most studies are in animals or in vitro, so direct applicability to humans is uncertain. Doses and forms were rarely reported, and few studies reached statistical significance.
  • Does Saccharomyces cerevisiae help with reducing inflammation?
    Six studies, including one human RCT (n=12), all reported beneficial effects on inflammation, with moderate effect sizes. However, evidence strength is low due to the small study base, potential publication bias, and limited human data. Three of the six studies reported statistically significant improvements.
  • Does Saccharomyces cerevisiae improve immune function?
    All 5 studies reported beneficial effects on immune function, with moderate effect sizes. However, none of the studies reached statistical significance, and populations varied widely (healthy adults, elderly, animals). The evidence is considered preliminary and low strength, with no human dose or form guidance available.

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