Saccharomyces cerevisiae and Reduced Inflammation

• Anti-inflammatory properties of a dried fermentate in vitro and in vivo.

  • 2015-03
  • RCT · n = 12
  • Journal of Medicinal Food 18(3)
  • • G. Jensen
    • Steve G. Carter
    • S. Reeves
    • Larry E. Robinson
    • K. Benson

  • PubMed: 25105458
  • DOI: 10.1089/jmf.2013.0158

  3 Insights on

  • Reduced Inflammation

  • High evidence

  Treatment of PMN cells in vitro resulted in reduced ROS formation and migratory activity toward Leukotriene B4. Clinical results demonstrated significantly reduced microvascular inflammatory responses to histamine-induced skin inflammation, and significantly reduced subjective scores of irritation at the inflamed sites treated with dried fermentate compared with the sites treated with placebo (P<.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.

  • 2025-12-12
  • Review
  • Veterinary sciences 12(12)
  • • Sahdeo Prasad
    • Bhaumik Patel
    • Prafulla Kumar
    • Rajiv Lall

  • PubMed: 41472171
  • DOI: 10.3390/vetsci12121191

  13 Insights on

  • Reduced Inflammation

  • Low evidence

  They also inhibit pro-inflammatory molecules like TNF-α and IL-6, while enhancing the anti-inflammatory cytokine IL-10.

  Effect

  Beneficial

  Effect size

  Moderate

• The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro.

  • 2014-05-22
  • BMC microbiology 14(1)
  • • Massimo Marzorati
    • Barbara Vanhoecke
    • Tine De Ryck
    • Mehdi Sadaghian Sadabad
    • Iris Pinheiro
    • Sam Possemiers
    • Pieter Van den Abbeele
    • Lara Derycke
    • Marc Bracke
    • Jan Pieters
    • Tom Hennebel
    • Hermie J Harmsen
    • Willy Verstraete
    • Tom Van de Wiele

  • PubMed: 24884540
  • DOI: 10.1186/1471-2180-14-133

  2 Insights on

  • Reduced Inflammation

  • Low evidence
  • Highly Cited

  the latter--with known anti-inflammatory properties--induced a decrease of pro-inflammatory IL-8 production between 24 and 48 h.

  Effect

  Beneficial

  Effect size

  Small

• A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.

  • 2013-09-19
  • Journal of agricultural and food chemistry 61(39)
  • • Sam Possemiers
    • Iris Pinheiro
    • An Verhelst
    • Pieter Van den Abbeele
    • Lois Maignien
    • Debby Laukens
    • Stuart G Reeves
    • Larry E Robinson
    • Thomas Raas
    • Yves-Jacques Schneider
    • Tom Van de Wiele
    • Massimo Marzorati

  • PubMed: 24006902
  • DOI: 10.1021/jf402137r

  4 Insights on

  • Reduced Inflammation

  • Low evidence
  • Rigorous Journal

  a significant decrease in pro-inflammatory cytokines was observed at the end of the treatment period

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Purification and Characterization of Novel Antihypertensive and Antioxidative Peptides From Whey Protein Fermentate: In Vitro, In Silico, and Molecular Interactions Studies.

  • 2022-11-23
  • Journal of the American Nutrition Association 42(6)
  • • Keval Chopada
    • Bethsheba Basaiawmoit
    • Amar A Sakure
    • Ruchika Maurya
    • Mahendra Bishnoi
    • Kanthi Kiran Kondepudi
    • Divyang Solanki
    • B P Singh
    • B P Singh
    • Srichandan Padhi
    • Amit Kumar Rai
    • Zhenbin Liu
    • B K Mishra
    • Subrota Hati

  • PubMed: 36416542
  • DOI: 10.1080/27697061.2022.2110966

  3 Insights on

  • Reduced Inflammation

  • Low evidence

  Whey protein fermentate has anti-inflammatory action in RAW 264.7 macrophages that have been exposed to lipopolysaccharide.

  Effect

  Beneficial

  Effect size

  Moderate

• Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.

  • 2019-02-20
  • BMC complementary and alternative medicine 19(1)
  • • Jong-Min Lim
    • Chang-Hyun Song
    • Su-Jin Park
    • Dong-Chan Park
    • Go-Woon Jung
    • Hyung-Rae Cho
    • Khawaja Muhammad Imran Bashir
    • Sae Kwang Ku
    • Jae-Suk Choi

  • PubMed: 30786935
  • DOI: 10.1186/s12906-019-2457-0

  6 Insights on

  • Reduced Inflammation

  • Low evidence
  • Animal Study

  The findings of the present study show that an oral administration of FBe had positive gastroprotective effects through strengthening the body antioxidant defense system and anti-inflammatory effects.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune models.

  • 2012-08-23
  • Evidence-based complementary and alternative medicine : eCAM 2012
  • • Malkanthi Evans
    • Stuart Reeves
    • Larry E Robinson

  • PubMed: 22548124
  • DOI: 10.1155/2012/973041

  3 Insights on

  • Reduced Inflammation

  • Low evidence

  DF significantly (P < 0.05) reduced swelling at all time points (1, 2, 3, 6, 12, and 24 hours) versus the control. Edema severity and PGE2 levels were reduced by approximately 50% and 25% (P < 0.05), respectively.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes