Saccharomyces cerevisiae and Reduced Inflammation

Research synthesisLow evidenceModerate effect6 studies · 6 beneficial · 0 neutral · 0 harmful

Across 6 studies, all reported beneficial effects of Saccharomyces cerevisiae on reducing inflammation, with effect sizes ranging from small to large and a predominant moderate effect. Statistically significant findings were observed in 3 studies, including a small RCT (n=12) showing reduced microvascular inflammation and subjective irritation scores. Most evidence comes from in vitro or animal models, limiting direct applicability to humans.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The evidence base is small (only 6 studies) — conclusions should be considered preliminary. Only one RCT in humans (n=12) was identified; the remainder are in vitro or animal studies, which limits generalizability to human populations. Doses and forms were not consistently reported across studies.

Generated May 12, 2026

7 of 7 papers

Anti-inflammatory properties of a dried fermentate in vitro and in vivo.
- 2015-03
- RCT · n = 12
- Journal of Medicinal Food 18(3)
- - G. Jensen
  - Steve G. Carter
  - S. Reeves
  - Larry E. Robinson
  - K. Benson
- PubMed: 25105458
- DOI: 10.1089/jmf.2013.0158
3 Insights on
- Reduced Inflammation
- High evidence
Treatment of PMN cells in vitro resulted in reduced ROS formation and migratory activity toward Leukotriene B4. Clinical results demonstrated significantly reduced microvascular inflammatory responses to histamine-induced skin inflammation, and significantly reduced subjective scores of irritation at the inflamed sites treated with dried fermentate compared with the sites treated with placebo (P<.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.
- 2025-12-12
- Review
- Veterinary sciences 12(12)
- - Sahdeo Prasad
  - Bhaumik Patel
  - Prafulla Kumar
  - Rajiv Lall
- PubMed: 41472171
- DOI: 10.3390/vetsci12121191
13 Insights on
- Reduced Inflammation
- Low evidence
They also inhibit pro-inflammatory molecules like TNF-α and IL-6, while enhancing the anti-inflammatory cytokine IL-10.
Effect
Beneficial
Effect size
Moderate
The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro.
- 2014-05-22
- BMC microbiology 14(1)
- - Massimo Marzorati
  - Barbara Vanhoecke
  - Tine De Ryck
  - Mehdi Sadaghian Sadabad
  - Iris Pinheiro
  - Sam Possemiers
  - Pieter Van den Abbeele
  - Lara Derycke
  - Marc Bracke
  - Jan Pieters
  - Tom Hennebel
  - Hermie J Harmsen
  - Willy Verstraete
  - Tom Van de Wiele
- PubMed: 24884540
- DOI: 10.1186/1471-2180-14-133
2 Insights on
- Reduced Inflammation
- Low evidence
- Highly Cited
the latter--with known anti-inflammatory properties--induced a decrease of pro-inflammatory IL-8 production between 24 and 48 h.
Effect
Beneficial
Effect size
Small
A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.
- 2013-09-19
- Journal of agricultural and food chemistry 61(39)
- - Sam Possemiers
  - Iris Pinheiro
  - An Verhelst
  - Pieter Van den Abbeele
  - Lois Maignien
  - Debby Laukens
  - Stuart G Reeves
  - Larry E Robinson
  - Thomas Raas
  - Yves-Jacques Schneider
  - Tom Van de Wiele
  - Massimo Marzorati
- PubMed: 24006902
- DOI: 10.1021/jf402137r
4 Insights on
- Reduced Inflammation
- Low evidence
- Rigorous Journal
a significant decrease in pro-inflammatory cytokines was observed at the end of the treatment period
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Purification and Characterization of Novel Antihypertensive and Antioxidative Peptides From Whey Protein Fermentate: In Vitro, In Silico, and Molecular Interactions Studies.
- 2022-11-23
- Journal of the American Nutrition Association 42(6)
- - Keval Chopada
  - Bethsheba Basaiawmoit
  - Amar A Sakure
  - Ruchika Maurya
  - Mahendra Bishnoi
  - Kanthi Kiran Kondepudi
  - Divyang Solanki
  - B P Singh
  - B P Singh
  - Srichandan Padhi
  - Amit Kumar Rai
  - Zhenbin Liu
  - B K Mishra
  - Subrota Hati
- PubMed: 36416542
- DOI: 10.1080/27697061.2022.2110966
3 Insights on
- Reduced Inflammation
- Low evidence
Whey protein fermentate has anti-inflammatory action in RAW 264.7 macrophages that have been exposed to lipopolysaccharide.
Effect
Beneficial
Effect size
Moderate
Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.
- 2019-02-20
- BMC complementary and alternative medicine 19(1)
- - Jong-Min Lim
  - Chang-Hyun Song
  - Su-Jin Park
  - Dong-Chan Park
  - Go-Woon Jung
  - Hyung-Rae Cho
  - Khawaja Muhammad Imran Bashir
  - Sae Kwang Ku
  - Jae-Suk Choi
- PubMed: 30786935
- DOI: 10.1186/s12906-019-2457-0
6 Insights on
- Reduced Inflammation
- Low evidence
- Animal Study
The findings of the present study show that an oral administration of FBe had positive gastroprotective effects through strengthening the body antioxidant defense system and anti-inflammatory effects.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune models.
- 2012-08-23
- Evidence-based complementary and alternative medicine : eCAM 2012
- - Malkanthi Evans
  - Stuart Reeves
  - Larry E Robinson
- PubMed: 22548124
- DOI: 10.1155/2012/973041
3 Insights on
- Reduced Inflammation
- Low evidence
DF significantly (P < 0.05) reduced swelling at all time points (1, 2, 3, 6, 12, and 24 hours) versus the control. Edema severity and PGE2 levels were reduced by approximately 50% and 25% (P < 0.05), respectively.
Effect
Beneficial
Effect size
Large
Significant
Yes

Saccharomyces cerevisiae and Reduced Inflammation

Anti-inflammatory properties of a dried fermentate in vitro and in vivo.

Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro.

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.

Purification and Characterization of Novel Antihypertensive and Antioxidative Peptides From Whey Protein Fermentate: In Vitro, In Silico, and Molecular Interactions Studies.

Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.

A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune models.