Saccharomyces cerevisiae and Reduced Blood Pressure

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on blood pressure-related outcomes, with effect sizes ranging from small to moderate. However, none of the studies reached statistical significance, and the evidence is derived entirely from in vitro and in silico peptide analyses rather than human trials.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All studies are in vitro or in silico analyses of peptide sequences; no human trials were identified. Effects observed in laboratory settings may not translate to clinical blood pressure reduction. Many of the included studies did not report statistical significance — effect may be smaller than the predominant direction suggests. Available evidence is overwhelmingly positive, but the small number of studies and lack of human data indicate publication bias may be a concern.

Generated Jul 12, 2026

3 of 3 papers

Purification and Characterization of Novel Antihypertensive and Antioxidative Peptides From Whey Protein Fermentate: In Vitro, In Silico, and Molecular Interactions Studies.
- 2022-11-23
- Journal of the American Nutrition Association 42(6)
- - Keval Chopada
  - Bethsheba Basaiawmoit
  - Amar A Sakure
  - Ruchika Maurya
  - Mahendra Bishnoi
  - Kanthi Kiran Kondepudi
  - Divyang Solanki
  - B P Singh
  - B P Singh
  - Srichandan Padhi
  - Amit Kumar Rai
  - Zhenbin Liu
  - B K Mishra
  - Subrota Hati
- PubMed: 36416542
- DOI: 10.1080/27697061.2022.2110966
3 Insights on
- Reduced Blood Pressure
- Low evidence
novel angiotensin-converting enzyme (ACE)-inhibitory... peptides from fermented whey protein concentrate produced by Lactobacillus paracasei and Saccharomyces cerevisiae
Effect
Beneficial
Effect size
Moderate
Antihypertensive peptides from whey proteins fermented by lactic acid bacteria.
- 2018-07-06
- Food science and biotechnology 27(6)
- - Eric Banan-Mwine Daliri
  - Byong H Lee
  - Byun-Jae Park
  - Se-Hun Kim
  - Deog-Hwan Oh
- PubMed: 30483443
- DOI: 10.1007/s10068-018-0423-0
3 Insights on
- Reduced Blood Pressure
- Low evidence
could be used as a starter culture in the dairy industry to develop antihypertensive functional foods for hypertension management
Effect
Beneficial
Effect size
Moderate
Identification of Antihypertensive Peptides Derived from Low Molecular Weight Casein Hydrolysates Generated during Fermentation by Bifidobacterium longum KACC 91563.
- 2015-12-31
- Korean journal for food science of animal resources 35(6)
- - Go Eun Ha
  - Oun Ki Chang
  - Su-Mi Jo
  - Gi-Sung Han
  - Beom-Young Park
  - Jun-Sang Ham
  - Seok-Geun Jeong
- PubMed: 26877633
- DOI: 10.5851/kosfa.2015.35.6.738
1 Insight on
- Reduced Blood Pressure
- Low evidence
Three peptides... corresponded to known antihypertensive peptides... We also found 15 peptides that were identified as potential antihypertensive peptides
Effect
Beneficial
Effect size
Small

Saccharomyces cerevisiae and Reduced Blood Pressure

Purification and Characterization of Novel Antihypertensive and Antioxidative Peptides From Whey Protein Fermentate: In Vitro, In Silico, and Molecular Interactions Studies.

Antihypertensive peptides from whey proteins fermented by lactic acid bacteria.

Identification of Antihypertensive Peptides Derived from Low Molecular Weight Casein Hydrolysates Generated during Fermentation by Bifidobacterium longum KACC 91563.