Best Supplements for Reduced Blood Pressure
Ranked by research evidence. Compare 100 supplements across 125 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across 3 studies (2 reviews and 1 meta-analysis), 2 reported beneficial effects on blood pressure with small to moderate effect sizes, while one meta-analysis in patients with type 2 diabetes or hyperglycemia found no significant effect.
- Low evidence4 studies
Across 4 studies, 2 reported beneficial small effects on blood pressure, while 2 found neutral results. The evidence is mixed, with the strongest study (a meta-analysis of 2,028 women) showing no effect. Among studies with beneficial findings, effect sizes were consistently small. The median study duration was 84 days, but this came from only 1 of 4 studies.
- Low evidence3 studies
Across 3 studies, 1 reported a beneficial moderate-sized effect on blood pressure reduction, while 2 found no significant difference between berberine and placebo. The predominant effect direction is neutral, and effect sizes were mixed (small to moderate). The most-studied dose is 500 mg twice daily (1000-1200 mg/day), and effects were typically observed over 12 weeks in clinical populations with hyperlipidemia, type 2 diabetes, or obesity.
Dose: 500 mg twice daily (1000-1200 mg/day)
- Very lowSaccharomyces cerevisiaeAcross 3 studies, all reported beneficial effects on blood pressure-related outcomes, with effect sizes ranging from small to moderate. However, none of the studies reached statistical significance, and the evidence is derived entirely from in vitro and in silico peptide analyses rather than human trials.3 beneficial3 studies
- LowL-CitrullineAcross 4 studies, 2 reported beneficial small effects on blood pressure, while 2 found neutral results. The evidence is mixed, with the strongest study (a meta-analysis of 2,028 women) showing no effect. Among studies with beneficial findings, effect sizes were consistently small. The median study duration was 84 days, but this came from only 1 of 4 studies.2 beneficial2 neutral4 studies
- ModerateTurmericAcross 3 studies (2 reviews and 1 meta-analysis), 2 reported beneficial effects on blood pressure with small to moderate effect sizes, while one meta-analysis in patients with type 2 diabetes or hyperglycemia found no significant effect.2 beneficial1 neutral3 studies
- Very lowOlive OilAcross 3 studies, 2 report beneficial effects (one moderate, one small) and 1 neutral effect. The only statistically significant finding comes from a review citing large-scale trials (PREDIMED, Seven Countries Study). Predominant effect size appears mixed (small to moderate) due to conflicting systematic review results. No dose range or population can be determined from available data.2 beneficial1 neutral3 studies
- LowBerberineAcross 3 studies, 1 reported a beneficial moderate-sized effect on blood pressure reduction, while 2 found no significant difference between berberine and placebo. The predominant effect direction is neutral, and effect sizes were mixed (small to moderate). The most-studied dose is 500 mg twice daily (1000-1200 mg/day), and effects were typically observed over 12 weeks in clinical populations with hyperlipidemia, type 2 diabetes, or obesity. · Dose: 500 mg twice daily (1000-1200 mg/day)1 beneficial2 neutral3 studies