Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

L-Citrulline and Reduced Blood Pressure

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, only 1 reported a beneficial small effect of L-citrulline on reducing blood pressure, while 2 found neutral effects. The evidence base is small and preliminary, with the only statistically significant finding coming from a review, not from the larger meta-analysis or RCT. Effects were predominantly small or none, and no consistent dose or form was identified across studies. The median study duration was 84 days (one study), but this is insufficient to generalize.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jun 11, 2026
Time to effect
Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 3 studies
3 of 3 papers
Back to top