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Evidence-Based Supplement Research
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Peppermint

Safety profile

5 studies reporting safety data1 increased-risk finding

Across 5 clinical studies, peppermint was associated with an increased risk of any adverse event in one study (RR 1.57; 95% CI 1.04–2.37). However, four other studies reported no significant difference in specific safety endpoints such as nausea, vomiting, and antiemetic use, or described the supplement as generally well tolerated. No serious adverse events were reported.

Caveats: Evidence is limited to short-term studies; long-term safety not established. Most studies were designed for efficacy, not safety, so rare adverse events may not be detected. Limited evidence base (5 studies); absence of reported events does not confirm safety.

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