Best Supplements for Improved Intestinal Barrier Function
Ranked by research evidence. Compare 86 supplements across 139 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence5 studies
Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus amylovorus on intestinal barrier function. Two of the three studies achieved statistical significance, and the evidence is derived primarily from animal models (piglets, sows, and lambs). No consistent dose range or study duration was reported across studies.
- Low evidence5 studies
Across 3 studies, all reported beneficial effects of Saccharomyces cerevisiae-based interventions on intestinal barrier function, with effect sizes ranging from moderate to large, and 2 of 3 findings were statistically significant. Most often assessed in animal models (broilers, aging mice) and in vitro cell systems, with no consistent dose or duration data extracted across studies.
- Low evidence4 studies
Across 4 studies, all reported beneficial moderate-sized effects on intestinal barrier function, with 2 reaching statistical significance. However, most studies were preclinical (cell or mouse models), and the interventions varied (including different probiotic strains and postbiotics), so direct evidence for Lactobacillus rhamnosus specifically is limited.
- Very lowLactobacillus brevis SBC8803Across 5 studies, all reported beneficial effects on intestinal barrier function. The predominant effect size was moderate. No specific dose, form, or population was consistently reported across the studies, and study durations were not consistently documented.8 beneficial8 studies
- LowLactobacillus amylovorusAcross 3 studies, all reported beneficial moderate-sized effects of Lactobacillus amylovorus on intestinal barrier function. Two of the three studies achieved statistical significance, and the evidence is derived primarily from animal models (piglets, sows, and lambs). No consistent dose range or study duration was reported across studies.5 beneficial5 studies
- LowSaccharomyces cerevisiaeAcross 3 studies, all reported beneficial effects of Saccharomyces cerevisiae-based interventions on intestinal barrier function, with effect sizes ranging from moderate to large, and 2 of 3 findings were statistically significant. Most often assessed in animal models (broilers, aging mice) and in vitro cell systems, with no consistent dose or duration data extracted across studies.5 beneficial5 studies
- LowLactobacillus rhamnosusAcross 4 studies, all reported beneficial moderate-sized effects on intestinal barrier function, with 2 reaching statistical significance. However, most studies were preclinical (cell or mouse models), and the interventions varied (including different probiotic strains and postbiotics), so direct evidence for Lactobacillus rhamnosus specifically is limited.4 beneficial4 studies
- Very lowBifidobacterium animalis subsp. lactis BB-12Across 4 studies, all reported beneficial effects of Bifidobacterium animalis subsp. lactis BB-12 on intestinal barrier function, with effect sizes ranging from small to moderate. Two studies showed moderate effects, one showed a small effect, and one did not specify an effect size. The evidence is primarily from in vitro and animal models, with no human trials and no statistically significant findings reported. No consistent dose or study duration was identified.4 beneficial4 studies