Best Supplements for Improved Intestinal Barrier Function
Ranked by research evidence. Compare 85 supplements across 138 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence8 studies
Across 5 studies, all reported beneficial effects on intestinal barrier function, with effect sizes predominantly moderate. However, none of the studies reported statistically significant findings, and the evidence base consists primarily of reviews and preclinical (cell/animal) models. No consistent dose or form data were available across the studies.
- Low evidence5 studies
Across 3 studies (all animal or cell-based), supplementation with Saccharomyces cerevisiae (yeast hydrolysate or in fermented products) consistently showed beneficial effects on intestinal barrier function, with predominantly moderate effect sizes. Two of the three studies reported statistically significant improvements. No human trials were identified, and study durations and doses were not consistently reported.
- Low evidence5 studies
Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus amylovorus on intestinal barrier function, with 2 reaching statistical significance. The evidence is based primarily on animal models (piglets, sows, lambs), limiting direct applicability to humans.
- LowLactobacillus brevis SBC8803Across 5 studies, all reported beneficial effects on intestinal barrier function, with effect sizes predominantly moderate. However, none of the studies reported statistically significant findings, and the evidence base consists primarily of reviews and preclinical (cell/animal) models. No consistent dose or form data were available across the studies.8 beneficial8 studies
- LowSaccharomyces cerevisiaeAcross 3 studies (all animal or cell-based), supplementation with Saccharomyces cerevisiae (yeast hydrolysate or in fermented products) consistently showed beneficial effects on intestinal barrier function, with predominantly moderate effect sizes. Two of the three studies reported statistically significant improvements. No human trials were identified, and study durations and doses were not consistently reported.5 beneficial5 studies
- LowLactobacillus amylovorusAcross 3 studies, all reported beneficial moderate-sized effects of Lactobacillus amylovorus on intestinal barrier function, with 2 reaching statistical significance. The evidence is based primarily on animal models (piglets, sows, lambs), limiting direct applicability to humans.5 beneficial5 studies
- LowBifidobacterium animalis subsp. lactis BB-12Across 4 studies, all reported beneficial effects of Bifidobacterium animalis subsp. lactis BB-12 on intestinal barrier function, with effect sizes ranging from small to moderate (predominantly moderate). Evidence includes a systematic review on colitis disease and in vitro work showing increased transepithelial electrical resistance. No consistent dose or study duration emerges from the available data, and most studies examined animal or cell models rather than healthy humans.4 beneficial4 studies
- Very lowLactobacillus rhamnosusAcross 4 studies, all reported beneficial moderate-sized effects of Lactobacillus rhamnosus on intestinal barrier function, with 2 studies reaching statistical significance. Evidence is drawn from in vitro and animal models; no human trials are included in this dataset.4 beneficial4 studies