Lactobacillus amylovorus and Improved Intestinal Barrier Function

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus amylovorus on intestinal barrier function, with 2 reaching statistical significance. The evidence is based primarily on animal models (piglets, sows, lambs), limiting direct applicability to humans.

Studied populations: Newborn mice/piglets, pregnant sows, weaned lambs

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All studies were conducted in animal populations (piglets, sows, lambs) rather than humans, so relevance to human intestinal barrier function is uncertain.

Generated May 12, 2026

5 of 5 papers

Lactobacillus amylovorus Promotes Lactose Utilization in Small Intestine and Enhances Intestinal Barrier Function in Intrauterine Growth Restricted Piglets.
- 2024-02
- Clinical Trial
- The Journal of nutrition 154(2)
- - Yujun Wu
  - Xiaoyi Liu
  - Youwei Zou
  - Xiangyu Zhang
  - Zhenyu Wang
  - Jie Hu
  - Dandan Han
  - Jinbiao Zhao
  - Zhaolai Dai
  - Junjun Wang
- PubMed: 38072153
- DOI: 10.1016/j.tjnut.2023.12.004
3 Insights on
- Improved Intestinal Barrier Function
- Moderate evidence
L. amylovorus Mafic1501 promoted intestinal barrier functions by increasing the villus height and relative gene expressions of tight junctions (P < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dietary Bacillus subtilis PB6 Enhances Reproductive Performance by Modulating Gut Microbiota, Barrier Function, and Inflammation in Clostridium perfringens Type A-Infected Sows.
- 2026-03-27
- Animals : an open access journal from MDPI 16(7)
- - Mengran Zhang
  - Aohang Yu
  - Chihao Wang
  - Chaojie Chen
  - Chenchen Wu
- PubMed: 41976011
- DOI: 10.3390/ani16071032
3 Insights on
- Improved Intestinal Barrier Function
- Low evidence
These probiotics can repair the intestinal tissue and improve intestinal histomorphology, and enhance the expression of MUC2 and sIgA in sows, thereby further strengthening the mucosal immune function.
Effect
Beneficial
Effect size
Moderate
Gut microbiota-driven IL-17/PPAR axis mediates epigallocatechin-induced intestinal repair in weaned lambs.
- 2026-04-04
- Journal of animal science and biotechnology 17(1)
- - Yuwei Zhao
  - Zhuo Wang
  - Dingkun Fan
  - Jixian Zhang
  - Yan Tu
  - Qiyu Diao
  - Kai Cui
- PubMed: 41933424
- DOI: 10.1186/s40104-026-01371-5
5 Insights on
- Improved Intestinal Barrier Function
- Low evidence
Supplementation with 12.5 mg/kg EGC (LE) significantly improved growth performance, reduced diarrhea incidence (P < 0.05), enhanced mucosal antioxidant capacity (P < 0.001), and strengthened anti-inflammatory ability (P < 0.001).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotic-derived extracellular vesicles alleviate AFB1-induced intestinal injury by modulating the gut microbiota and AHR activation.
- 2024-11-11
- Journal of nanobiotechnology 22(1)
- - Jinyan Li
  - Mengdie Shi
  - Yubo Wang
  - Jinyan Liu
  - Shuiping Liu
  - Weili Kang
  - Xianjiao Liu
  - Xingxiang Chen
  - Kehe Huang
  - Yunhuan Liu
- PubMed: 39529091
- DOI: 10.1186/s12951-024-02979-3
4 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Animal Study
decreasing intestinal permeability and increasing the expression of tight junction proteins
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles.
- 2023-09-28
- Nutrients 15(19)
- - Shengkai Feng
  - Yihan Liu
  - Jing Xu
  - Jinping Fan
  - Jingjing Li
  - Zhifeng Wu
  - Yue Sun
  - Wen Xiong
- PubMed: 37836484
- DOI: 10.3390/nu15194198
3 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Rigorous Journal
- Animal Study
three of them alleviated intestinal oxidative stress and protected the intestinal barrier
Effect
Beneficial
Effect size
Moderate

Lactobacillus amylovorus and Improved Intestinal Barrier Function

Lactobacillus amylovorus Promotes Lactose Utilization in Small Intestine and Enhances Intestinal Barrier Function in Intrauterine Growth Restricted Piglets.

Dietary Bacillus subtilis PB6 Enhances Reproductive Performance by Modulating Gut Microbiota, Barrier Function, and Inflammation in Clostridium perfringens Type A-Infected Sows.

Gut microbiota-driven IL-17/PPAR axis mediates epigallocatechin-induced intestinal repair in weaned lambs.

Probiotic-derived extracellular vesicles alleviate AFB1-induced intestinal injury by modulating the gut microbiota and AHR activation.

Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles.