Lactobacillus brevis SBC8803 and Improved Intestinal Barrier Function

Research synthesisLow evidenceModerate effect5 studies · 5 beneficial · 0 neutral · 0 harmful

Across 5 studies, all reported beneficial effects on intestinal barrier function, with effect sizes predominantly moderate. However, none of the studies reported statistically significant findings, and the evidence base consists primarily of reviews and preclinical (cell/animal) models. No consistent dose or form data were available across the studies.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Furthermore, none of the included studies reported statistically significant findings, indicating that the effect may be smaller or less reliable than the predominant direction suggests. The evidence is heavily based on reviews and preclinical models; human clinical trials are lacking.

Generated May 12, 2026

8 of 8 papersPopulation:

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders.
- 2015-10-14
- Review
- Frontiers in cellular neuroscience 9
- - John R Kelly
  - Paul J Kennedy
  - John F Cryan
  - Timothy G Dinan
  - Gerard Clarke
  - Niall P Hyland
- PubMed: 26528128
- DOI: 10.3389/fncel.2015.00392
3 Insights on
- Improved Intestinal Barrier Function
- Moderate evidence
- Highly Cited
the gut microbiome plays a critical role in regulating intestinal permeability. In this review we will discuss the possible role played by the gut microbiota in maintaining intestinal barrier function and the CNS consequences when it becomes disrupted.
Effect
Beneficial
Effect size
Moderate
Selection of Fermentation Supernatant from Probiotic Strains Exhibiting Intestinal Epithelial Barrier Protective Ability and Evaluation of Their Effects on Colitis Mouse and Weaned Piglet Models.
- 2024-04-12
- Nutrients 16(8)
- - Solomon Abrehame
  - Man-Yun Hung
  - Yu-Yi Chen
  - Yu-Tse Liu
  - Yung-Tsung Chen
  - Fang-Chueh Liu
  - Yu-Chun Lin
  - Yen-Po Chen
- PubMed: 38674829
- DOI: 10.3390/nu16081138
4 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Rigorous Journal
selected specific cell-free fermentation supernatants (CFSs) from Ligilactobacillus salivarius P1, Lactobacillus gasseri P12, and Limosilactobacillus reuteri G7 promoted intestinal epithelial cell growth and proliferation, strengthening the intestinal barrier in an intestinal epithelial cell line Caco-2 model
Effect
Beneficial
Effect size
Moderate
Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota.
- 2016-02-16
- Review
- Nutrition reviews 74(3)
- - Marie-Edith Arnal
  - Jean-Paul Lallès
- PubMed: 26883882
- DOI: 10.1093/nutrit/nuv104
1 Insight on
- Improved Intestinal Barrier Function
- Low evidence
The probiotic strain was associated with enhanced intestinal barrier function through upregulation of inducible heat-shock proteins, which protect the gut epithelium against oxidative stress and inflammation.
Effect
Beneficial
Effect size
Moderate
Diet, microbiome, and the intestinal epithelium: an essential triumvirate?
- 2013-11-11
- Review
- BioMed research international 2013
- - Javier Rivera Guzman
  - Victoria Susan Conlin
  - Christian Jobin
- PubMed: 23586037
- DOI: 10.1155/2013/425146
1 Insight on
- Improved Intestinal Barrier Function
- Low evidence
The abstract addresses the role of bacteria, bacterial-derived metabolism, and the interplay of dietary factors in controlling intestinal barrier function.
Effect
Beneficial
Effect size
Small
Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway.
- 2011-08-15
- PloS one 6(8)
- - Shuichi Segawa
  - Mikihiro Fujiya
  - Hiroaki Konishi
  - Nobuhiro Ueno
  - Naoyuki Kobayashi
  - Tatsuro Shigyo
  - Yutaka Kohgo
- PubMed: 21858054
- DOI: 10.1371/journal.pone.0023278
3 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Highly Cited
poly P suppressed the oxidant-induced intestinal permeability in the mouse small intestine
Effect
Beneficial
Effect size
Moderate
Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators.
- 2021-01
- Mediators of inflammation 2021(1)
- - Shotaro Isozaki
  - Hiroaki Konishi
  - Mikihiro Fujiya
  - Hiroki Tanaka
  - Yuki Murakami
  - Shin Kashima
  - Katsuyoshi Ando
  - Nobuhiro Ueno
  - Kentaro Moriichi
  - Toshikatsu Okumura
- PubMed: 33859537
- DOI: 10.1155/2021/5582943
3 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Animal Study
We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved the intestinal barrier function by the upregulation of cell adhesion and relieved intestinal inflammation
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.
- 2012-07-01
- American journal of physiology. Gastrointestinal and liver physiology 303(1)
- - Yuhua Wang
  - Yanlong Liu
  - Anju Sidhu
  - Zhenhua Ma
  - Craig McClain
  - Wenke Feng
- PubMed: 22538402
- DOI: 10.1152/ajpgi.00024.2012
2 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Highly Cited
- Animal Study
LGG-s pretreatment significantly inhibited the alcohol-induced intestinal permeability, endotoxemia and subsequently liver injury.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Heat‐killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function
- 2011-11
- Clinical Trial
- Inflammatory Bowel Diseases 17(11)
- - N. Ueno
  - M. Fujiya
  - S. Segawa
  - T. Nata
  - K. Moriichi
  - H. Tanabe
  - Y. Mizukami
  - N. Kobayashi
  - Kazutoshi Ito
  - Y. Kohgo
- PubMed: 21987297
- DOI: 10.1002/ibd.21597
9 Insights on
- Improved Intestinal Barrier Function
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
- Clinical
Heat‐killed L. brevis SBC8803 induced Hsps, phosphorylated p38 MAPK, regulated the expression of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β and IL-12, and improved the barrier function of intestinal epithelia under oxidant stress.
Effect
Beneficial
Effect size
Moderate