Saccharomyces cerevisiae and Improved Intestinal Barrier Function

• Effects of yeast hydrolysate supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers.

  • 2022-06-01
  • RCT · n = 320
  • Animal bioscience 35(6)
  • • Ting Wang
    • Kang Cheng
    • QiMing Li
    • Tian Wang

  • PubMed: 34991218
  • DOI: 10.5713/ab.21.0374

  4 Insights on

  • Improved Intestinal Barrier Function

  • High evidence

  dietary YH supplementation linearly and quadratically decreased serum diamine oxidase activity... Whereas the jejunal villus height (VH), VH/CD, IL-10 concentration as well as zonula occludens-1 and IL-10 gene expression levels were linearly and/or quadratically increased by YH supplementation

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Lychee Fermented by Mixed Probiotic Strains Alleviates D-Galactose-Induced Skeletal Muscle and Intestinal Aging in Mice.

  • 2025-10-29
  • Foods (Basel, Switzerland) 14(21)
  • • Huixian Han
    • Jin Tao
    • Xiaoyue Bai
    • Yizhi Jing
    • Zhengyuan Zhai
    • Junjie Luo
    • Wanxiang Zhang
    • Dan Gan
    • Yanling Hao

  • PubMed: 41227656
  • DOI: 10.3390/foods14213684

  7 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  intervention with LF ameliorated the colonic tissue damage, preserved goblet cell populations and promoted MUC2-mediated mucus secretion, which was further confirmed by the upregulation of intestinal barrier-related proteins MUC2, ZO-1, Claudin-1, and Occludin

  Effect

  Beneficial

  Effect size

  Large

• Dietary Saccharomyces cerevisiae improves intestinal flora structure and barrier function of Pekin ducks.

  • 2023-01
  • RCT · n = 180
  • Poultry science 102(1)
  • • Wenwen Gao
    • Keying An
    • Peng Li
    • Lei Li
    • Zhaofei Xia

  • PubMed: 36436368
  • DOI: 10.1016/j.psj.2022.101940

  3 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  600 mg/kg SC supplemented, the mRNA levels of villin, claudin3, and MUC 2 in d21 were up-regulated, as well as the mRNA levels of villin, claudin3, occludin, i-FABP, ZO-1, and MUC 2 in d42.

  Effect

  Beneficial

  Effect size

  Moderate

• Fermentation Supernatants of Pleurotus eryngii Mushroom Ameliorate Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide-Induced Caco-2 Cells via Upregulation of Tight Junctions.

  • 2021-10-01
  • Microorganisms 9(10)
  • • Georgia Saxami
    • Evangelia N Kerezoudi
    • Evdokia K Mitsou
    • Georgios Koutrotsios
    • Georgios I Zervakis
    • Vasiliki Pletsa
    • Adamantini Kyriacou

  • PubMed: 34683391
  • DOI: 10.3390/microorganisms9102071

  1 Insight on

  • Improved Intestinal Barrier Function

  • Low evidence

  FSs from <i>P. eryngii</i> mushrooms led to a significant upregulation of the TJs gene expression in pre-incubation state, indicating potential preventive action.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats.

  • 2019-07-09
  • Journal of applied microbiology 127(4)
  • • H A G Ducray
    • L Globa
    • O Pustovyy
    • E Morrison
    • V Vodyanoy
    • I Sorokulova

  • PubMed: 31230390
  • DOI: 10.1111/jam.14361

  2 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  Oral treatment of rats with EH before stress significantly prevents these adverse effects by elevation of the gut beneficial bacteria, particularly butyrate-producing bacteria.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes