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Effects of yeast hydrolysate supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers.

  • 2022-06-01
  • Animal bioscience 35(6)

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 320
Population
320 one day old male broilers
Methods
320 one day old male broilers were randomly allocated into four groups with eight replicates of ten broilers each; the broilers were supplemented with a basal diet (the control group) or basal diets adding 50, 100, 150 mg/kg YH, respectively; this trial lasted for 42 days

Objective

This study was conducted to evaluate the effects of dietary yeast hydrolysate (YH) supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers.

Methods

A total of 320 one day old male broilers were randomly allocated into four groups with eight replicates of ten broilers each. The broilers were supplemented with a basal diet (the control group) or basal diets adding 50, 100, 150 mg/kg YH, respectively. This trial lasted for 42 days. The orthogonal polynomial contrasts were used to determine the linear and quadratic effects of increasing levels of YH.

Results

In our previous research, supplementing YH improved growth performance by enhancing body weight gain but decreased feed-to-gain ratio. In this study, compared with the control group, dietary YH addition linearly and quadratically decreased serum diamine oxidase activity (p<0.05). Additionally, supplementing YH linearly and/or quadratically decreased jejunal crypt depth (CD), tumor necrosis factor-alpha (TNF-α) concentration as well as mucin 2, interleukin-6 (IL-6), IL-1β, TNF-α, nuclear factor kappa B, and myeloid differentiation factor 88 gene expression levels (p<0.05). Whereas the jejunal villus height (VH), VH/CD, IL-10 concentration as well as zonula occludens-1 and IL-10 gene expression levels were linearly and/or quadratically increased by YH supplementation (p<0.05).

Conclusion

Dietary YH supplementation improved intestinal morphology, barrier and anti-inflammatory functions while decreased intestinal permeability of broilers, which might be related with altering pertinent genes expression. This study provides evidence of YH as a promising feed additive for broilers.

Research Insights

  • Saccharomyces cerevisiae→Improved Intestinal Barrier Function

    dietary YH supplementation linearly and quadratically decreased serum diamine oxidase activity... Whereas the jejunal villus height (VH), VH/CD, IL-10 concentration as well as zonula occludens-1 and IL-10 gene expression levels were linearly and/or quadratically increased by YH supplementation

    Effect
    Beneficial
    Effect size
    Moderate
  • Saccharomyces cerevisiae→Improved Intestinal Morphology

    supplementing YH linearly and/or quadratically decreased jejunal crypt depth (CD)... Whereas the jejunal villus height (VH), VH/CD... were linearly and/or quadratically increased by YH supplementation

    Effect
    Beneficial
    Effect size
    Moderate
  • Saccharomyces cerevisiae→Reduced Intestinal Inflammation

    supplementing YH linearly and/or quadratically decreased... tumor necrosis factor-alpha (TNF-α) concentration as well as mucin 2, interleukin-6 (IL-6), IL-1β, TNF-α, nuclear factor kappa B, and myeloid differentiation factor 88 gene expression levels

    Effect
    Beneficial
    Effect size
    Moderate
  • Saccharomyces cerevisiae→Reduced Intestinal Permeability

    Dietary YH supplementation improved intestinal morphology, barrier and anti-inflammatory functions while decreased intestinal permeability of broilers

    Effect
    Beneficial
    Effect size
    Moderate
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