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Peppermint

Safety profile

5 studies reporting safety data1 increased-risk finding

Peppermint was associated with a statistically significant increase in overall adverse events in one meta-analysis (RR 1.57, 95% CI 1.04–2.37). Across five clinical studies, the majority of findings showed no significant difference between peppermint and control for specific events such as nausea, vomiting, antiemetic use, and blood pressure, with several studies also reporting peppermint as generally well tolerated. No serious adverse events were flagged in any of the included trials.

Caveats: Evidence is limited to short-term studies; long-term safety not established. Studies were powered for efficacy rather than safety, and the increased risk finding comes from a meta-analysis that may reflect heterogeneity in formulations and populations studied.

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