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Saccharomyces boulardii

Safety profile

5 studies reporting safety data

Across 5 clinical studies, no specific adverse events were quantitatively elevated for Saccharomyces boulardii compared to control. In 2 analyses, the supplement showed no significant difference in adverse events or diarrhea after adjustment for multiple comparisons. Four studies described the probiotic as generally well-tolerated, with no serious adverse events reported.

Caveats: Most studies were short-term (≤4 weeks) and powered for efficacy rather than safety; rare adverse events may not have been detected. Evidence is limited to specific strains (e.g., CNCM I-745), and long-term safety data are lacking.

Most-studied combinations with Saccharomyces boulardii

most supplement research is combination research
Also studied with:Lactobacillus rhamnosus GG (2)

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