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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Saccharomyces boulardii and Reduced Duration of Diarrhea

Research synthesisModerate evidenceLarge effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on reducing the duration of diarrhea, with a predominant large effect size. The evidence is strongest in children with acute gastroenteritis, with a meta-analysis (n=1125) showing a reduction of 1.63 days (SMD=-1.63, 95% CI -2.08 to -1.18). No consistent dose or form data were reported across studies.

  • Studied populations: children with acute gastroenteritis

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Two of the three studies are narrative reviews, not primary data, which limits the strength of conclusions.

Generated Jun 19, 2026
Safety in these studies
3 of 3 papers
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