Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.

2023-10-01
Cureus 15(10)
- Sarath Gopalan
- Sridhar Ganapathy
- Monjori Mitra
- Neha
- Devesh Kumar Joshi
- Krishna C Veligandla
- Rahul Rathod
- Bhavesh P Kotak

PubMed: 37927652
DOI: 10.7759/cureus.46314

Study Design

Type: Review

Probiotics, both bacterial and yeast, have long been associated with a beneficial health history and human well-being. Among yeasts, Saccharomyces is a genus that is efficacious in rendering better human health, with Saccharomyces boulardii (S. boulardii) CNCM I-745 being classified as a probiotic agent. The present review highlights the unique properties of S. boulardii and its rolein the prevention of antibiotic-associated diarrhea (AAD) and pediatric acute gastroenteritis (PAGE) in comparison to bacterial probiotics. Its unique properties,such as viability over a wide pH range, inability to acquire antibiotic resistance genes, and property to achieve a steady state rapidly, have given S. boulardii an edge over bacterial probiotics. In AAD patients, prophylactic use of S. boulardii has shown a significantly lower risk of AAD (in comparison to controls) and restored the diversity of gut microbiota. Among Indian children with PAGE, S. boulardii CNCM I-745 was found superior to Lactobacillus rhamnosus GG and four strains of Bacillus clausii in shortening the duration of diarrhea and reducing the length of hospital stay. S. boulardii CNCM I-745 being considered a safe probiotic for use in children and adults also finds recommendations in several international guidelines for the management of acute diarrhea. The current review discusses evidence for the proven efficacy and safety of S. boulardii CNCM I-745 as a probiotic for preventing gastrointestinal disorders.

Research Insights

Saccharomyces boulardii→Reduced Diarrhea Rate
In AAD patients, prophylactic use of S. boulardii has shown a significantly lower risk of AAD (in comparison to controls) and restored the diversity of gut microbiota.
Effect
Beneficial
Effect size
Moderate
Saccharomyces boulardii→Reduced Duration of Diarrhea
Among Indian children with PAGE, S. boulardii CNCM I-745 was found superior to Lactobacillus rhamnosus GG and four strains of Bacillus clausii in shortening the duration of diarrhea and reducing the length of hospital stay.
Effect
Beneficial
Effect size
Large
Saccharomyces boulardii→Reduced Length of Hospital Stay
Among Indian children with PAGE, S. boulardii CNCM I-745 was found superior to Lactobacillus rhamnosus GG and four strains of Bacillus clausii in shortening the duration of diarrhea and reducing the length of hospital stay.
Effect
Beneficial
Effect size
Large

Adverse Events Reported

Saccharomyces boulardii→Overall tolerability
S. boulardii CNCM I-745 being considered a safe probiotic for use in children and adults also finds recommendations in several international guidelines for the management of acute diarrhea.
Finding
Reported