Best Supplements for Reduced Duration of Diarrhea
Ranked by research evidence. Compare 32 supplements across 46 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence5 studies
Across 5 studies, all reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea duration, with effect sizes ranging from small to large (mixed). Four of the five studies were statistically significant. The most common dose was approximately 10^8 CFU per day, and the evidence primarily comes from pediatric populations, including children with acute diarrhea, antibiotic-associated diarrhea, and healthy daycare attendees.
Dose: 10^8 CFU per day (1×10^8 to 2×10^8 CFU)Product matchBioGaia — Kids, Immune Active with L. Reuteri + Vitamin D, Orange· $26.99 · ★4.8 (510) - Moderate evidence3 studies
Across 3 studies, all reported beneficial effects on reducing diarrhea duration, with effect sizes ranging from small to large. The strongest evidence (a meta-analysis of 1125 children) showed a large effect (reduction of ~1.6 days). The evidence base is small and primarily limited to pediatric populations with acute gastroenteritis; dosing information was not consistently reported.
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects on reducing diarrhea duration, but the largest and highest-quality randomized controlled trial (n=943) found no significant difference. Effect sizes among beneficial studies were mixed (small to large). The most-studied dose was at least 10^10 CFU per day, and all studies focused on children with acute diarrhea.
Dose: ≥10^10 CFU per day (e.g., 1×10^10 CFU twice daily)
- ModerateLactobacillus reuteri DSM 17938Across 5 studies, all reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea duration, with effect sizes ranging from small to large (mixed). Four of the five studies were statistically significant. The most common dose was approximately 10^8 CFU per day, and the evidence primarily comes from pediatric populations, including children with acute diarrhea, antibiotic-associated diarrhea, and healthy daycare attendees. · Dose: 10^8 CFU per day (1×10^8 to 2×10^8 CFU)5 beneficial5 studies
- Very lowsaccharomyces boulardiiAcross 4 studies on saccharomyces boulardii for reducing diarrhea duration, 3 reported beneficial effects (predominantly small to moderate in size). The evidence is strongest in children with acute diarrhea, but the only meta-analysis showed a neutral effect with a non-significant mean difference. No consistent dose range or study duration was reported.3 beneficial1 neutral4 studies
- ModerateSaccharomyces boulardiiAcross 3 studies, all reported beneficial effects on reducing diarrhea duration, with effect sizes ranging from small to large. The strongest evidence (a meta-analysis of 1125 children) showed a large effect (reduction of ~1.6 days). The evidence base is small and primarily limited to pediatric populations with acute gastroenteritis; dosing information was not consistently reported.3 beneficial3 studies
- LowLactobacillus rhamnosus GGAcross 3 studies, 2 reported beneficial effects on reducing diarrhea duration, but the largest and highest-quality randomized controlled trial (n=943) found no significant difference. Effect sizes among beneficial studies were mixed (small to large). The most-studied dose was at least 10^10 CFU per day, and all studies focused on children with acute diarrhea. · Dose: ≥10^10 CFU per day (e.g., 1×10^10 CFU twice daily)2 beneficial1 neutral3 studies
- LowLactobacillus reuteri MAK02L14RAcross 3 studies, 2 reported beneficial effects of Lactobacillus reuteri MAK02L14R on reducing duration of diarrhea in children with acute gastroenteritis, while 1 found no significant benefit. The predominant effect size was mixed (small to large), with meta-analyses showing reductions of approximately 0.87 days and 32 hours. Dose and form data were not consistently reported.2 beneficial1 neutral3 studies