Best Supplements for Reduced Duration of Diarrhea
Ranked by research evidence. Compare 32 supplements across 46 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence5 studies
Across 5 studies, all reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea duration, with 4 reaching statistical significance. Effect sizes were mixed (small to large). The most studied dose was around 10^8 CFU/day, and the primary population was children.
Dose: 10^8 CFU/dayProduct matchBioGaia — Kids, Immune Active with L. Reuteri + Vitamin D, Orange· $26.99 · ★4.8 (510) - Moderate evidence4 studies
Across 4 studies, 3 reported beneficial effects of Saccharomyces boulardii on reducing diarrhea duration, predominantly with small effect sizes. The most studied population is children (especially under 5 with acute gastroenteritis), and no consistent dose range was reported across studies. One meta-analysis showed a neutral result, adding some uncertainty.
- Moderate evidence3 studies
Across 3 studies, all reported beneficial effects on reducing the duration of diarrhea, with a predominant large effect size. The evidence is strongest in children with acute gastroenteritis, with a meta-analysis (n=1125) showing a reduction of 1.63 days (SMD=-1.63, 95% CI -2.08 to -1.18). No consistent dose or form data were reported across studies.
- ModerateLactobacillus reuteri DSM 17938Across 5 studies, all reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea duration, with 4 reaching statistical significance. Effect sizes were mixed (small to large). The most studied dose was around 10^8 CFU/day, and the primary population was children. · Dose: 10^8 CFU/day5 beneficial5 studies
- Moderatesaccharomyces boulardiiAcross 4 studies, 3 reported beneficial effects of Saccharomyces boulardii on reducing diarrhea duration, predominantly with small effect sizes. The most studied population is children (especially under 5 with acute gastroenteritis), and no consistent dose range was reported across studies. One meta-analysis showed a neutral result, adding some uncertainty.3 beneficial1 neutral4 studies
- ModerateSaccharomyces boulardiiAcross 3 studies, all reported beneficial effects on reducing the duration of diarrhea, with a predominant large effect size. The evidence is strongest in children with acute gastroenteritis, with a meta-analysis (n=1125) showing a reduction of 1.63 days (SMD=-1.63, 95% CI -2.08 to -1.18). No consistent dose or form data were reported across studies.3 beneficial3 studies
- LowLactobacillus rhamnosus GGAcross 3 studies, 2 reported beneficial effects (one large, one small) and 1 high-quality RCT found no significant difference. Evidence predominantly supports reduced diarrhea duration in children, particularly at high doses (≥10^10 CFU/day), but effect sizes are mixed. · Dose: ≥10^10 CFU/day2 beneficial1 neutral3 studies
- LowLactobacillus reuteri MAK02L14RAcross the 3 identified studies on Lactobacillus reuteri MAK02L14R (studied as DSM 17938) for reducing diarrhea duration in children with acute gastroenteritis, 2 reported beneficial effects and 1 was neutral. Effect sizes ranged from small to large, with the most recent meta-analysis showing a small beneficial effect (mean difference -0.87 days). The evidence is predominantly in clinical pediatric populations with acute gastroenteritis; no consistent dose or form data were reported.2 beneficial1 neutral3 studies