Lactobacillus rhamnosus GG and Reduced Duration of Diarrhea

• Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children

  • 2018-11-22
  • RCT · n = 943
  • New England Journal of Medicine 379(21)
  • • D. Schnadower
    • P. Tarr
    • C. Casper
    • M. Gorelick
    • M. J. Dean
    • Karen J. O’Connell
    • P. Mahajan
    • A. Levine
    • S. Bhatt
    • C. Roskind
    • E. Powell
    • A. Rogers
    • C. Vance
    • R. Sapién
    • Cody S. Olsen
    • M. Metheney
    • Viani Dickey
    • C. Hall-Moore
    • S. Freedman

  • PubMed: 30462938
  • DOI: 10.1056/NEJMoa1802598

  5 Insights on

  • Reduced Duration of Diarrhea

  • High evidence
  • Large Human Trial
  • Highly Cited
  • Rigorous Journal

  There were no significant differences between the L. rhamnosus GG group and the placebo group in the duration of diarrhea (median, 49.7 hours in the L. rhamnosus GG group and 50.9 hours in the placebo group; P=0.26).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  1×10^10 colony-forming units twice daily